HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

The role of protein disulphide-isomerase A3 as autoantigen in the pathogenesis of autoimmune thyroiditis and related brain damage in adult mice.

Abstract
Autoimmune thyroiditis (AIT)-related brain damage is one of most severe extrathyroidal manifestations of AIT, but the mechanism remains unclear. In this study, we confirmed that protein disulfide-isomerase A3 (PDIA3) is expressed in both thyroid and brain tissues of mouse, and found the significantly increased serum levels of anti-PDIA3 antibody (PDIA3Ab) in classical mouse models of thyroiditis. In addition, we investigated the PDIA3-specific autoimmune reaction in thyroid and brain tissues in a mouse model with high-serum PDIA3Ab induced by immunization with recombinant PDIA3 protein. PDIA3-immunized mice had elevated serum thyrotropin and impaired learning and memory. PDIA3-expressing cells had IgG deposition, and IgG colocalized with C3 in the thyroid and brain tissues of PDIA3-immunized mice, resulting in membrane attack complex formation. Our results suggest that PDIA3 protein may be a common autoantigen shared by the thyroid and brain tissues and involve in the thyroidal and intracerebral damage through activating complement system.
AuthorsWenqing Yang, Yang Xiang, Hongmei Zhang, Zhongyan Shan, Jing Li, Weiping Teng
JournalClinical immunology (Orlando, Fla.) (Clin Immunol) Vol. 212 Pg. 108350 (03 2020) ISSN: 1521-7035 [Electronic] United States
PMID31982645 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2020. Published by Elsevier Inc.
Chemical References
  • Autoantibodies
  • Autoantigens
  • Pdia3 protein, mouse
  • Protein Disulfide-Isomerases
Topics
  • Animals
  • Apoptosis (immunology)
  • Autoantibodies (immunology)
  • Autoantigens (immunology)
  • Brain (immunology, pathology, physiopathology, ultrastructure)
  • Disease Models, Animal
  • Encephalitis (immunology, pathology, physiopathology)
  • Excitatory Postsynaptic Potentials (physiology)
  • Hashimoto Disease (immunology, pathology, physiopathology)
  • Long-Term Potentiation (physiology)
  • Maze Learning
  • Mice
  • Protein Disulfide-Isomerases (immunology)
  • Thyroid Gland (immunology, pathology)
  • Thyroiditis, Autoimmune (immunology, pathology, physiopathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: