Outer membrane protein A (OmpA) as a potential therapeutic target for Acinetobacter baumannii infection.

Abstract

Acinetobacter baumannii (A. baumannii) is an important opportunistic pathogen causing serious nosocomial infections, which is considered as the most threatening Gram-negative bacteria (GNB). Outer membrane protein A (OmpA), a major component of outer membrane proteins (OMPs) in GNB, is a key virulence factor which mediates bacterial biofilm formation, eukaryotic cell infection, antibiotic resistance and immunomodulation. The characteristics of OmpA in Escherichia coli (E. coli) have been extensively studied since 1974, but only in recent years researchers started to clarify the functions of OmpA in A. baumannii. In this review, we summarized the structure and functions of OmpA in A. baumannii (AbOmpA), collected novel therapeutic strategies against it for treating A. baumannii infection, and emphasized the feasibility of using AbOmpA as a potential therapeutic target.

• Authors: Dan Nie, Yue Hu, Zhou Chen, Mingkai Li, Zheng Hou, Xiaoxing Luo, Xinggang Mao, Xiaoyan Xue
• Journal: Journal of biomedical science (J Biomed Sci) Vol. 27 Issue 1 Pg. 26 (Jan 18 2020) ISSN: 1423-0127 [Electronic] England
• PMID: 31954394 (Publication Type: Journal Article, Review)

Chemical References

• Bacterial Outer Membrane Proteins
• OMPA outer membrane proteins

Topics

• Acinetobacter Infections (therapy)
• Acinetobacter baumannii (genetics, physiology)
• Bacterial Outer Membrane Proteins (genetics, metabolism)
• Humans