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Virulence Factors (Pathogenicity Factors)

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Those components of an organism that determine its capacity to cause disease but are not required for its viability per se. Two classes have been characterized: TOXINS, BIOLOGICAL and surface adhesion molecules that effect the ability of the microorganism to invade and colonize a host. (From Davis et al., Microbiology, 4th ed. p486)

Also Known As:

Pathogenicity Factors; Factors, Pathogenicity; Factors, Virulence

Networked: 1615 relevant articles (18 outcomes, 115 trials/studies) for this Bio-Agent, Comments

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Bio-Agent Context: Research Results

Experts

1.	Potempa, Jan: 7 articles (01/2010 - 10/2003)
2.	Yamaoka, Yoshio: 7 articles (03/2009 - 06/2002)
3.	Finlay, B Brett: 6 articles (02/2010 - 05/2005)
4.	Bingen, E: 5 articles (03/2010 - 04/2000)
5.	Arciola, Carla Renata: 5 articles (09/2009 - 05/2004)
6.	Aktories, Klaus: 5 articles (02/2009 - 09/2004)
7.	Schaller, M: 5 articles (12/2008 - 01/2000)
8.	Vandenesch, François: 4 articles (01/2010 - 11/2005)
9.	Kawabata, Shigetada: 4 articles (12/2009 - 10/2004)
10.	Sokol, Pamela A: 4 articles (09/2009 - 08/2002)

Related Diseases

1.	Infection 10/01/2007 - "aeruginosa lung infection that AZM treatment results in the suppression of QS-regulated virulence factors, significantly improves the clearance of P. " 10/01/2009 - "Analysis of stx subtypes and detection of additional virulence factors in eae-negative strains may help to better assess the risk of such strains for causing human infection." 01/01/2008 - "aureus strains has helped identify a number of virulence factors, but the key determinants for infection are still unknown. " 07/01/2002 - "The interplay between pathogen-encoded virulence factors and host cell signaling networks is critical for both the establishment and clearance of microbial infections. " 12/01/2009 - "Relatively little is known about the virulence factors associated with NCAC species, and the aim of this study was to use a reconstituted human oral epithelium (RHOE) to examine epithelial infection withCandida parapsilosis. " Order ALL the reference details at left...
2.	Urinary Tract Infections (Urinary Tract Infection) 10/01/2005 - "Determination of bacterial virulence factors causing urinary tract infections in children may be helpful in the prognosis of the course of the disease." 04/01/1996 - "The relationship between the presence of bacterial virulence factors and the severity of urinary tract infection (UTI) was analized in this study. " 03/01/1991 - "Earlier studies revealed several phenotypic Escherichia coli virulence factors that influenced both the anatomic level and severity of urinary tract infection. " 03/01/1991 - "Most of the information available concerning virulence factors of uropathogens is based on studies of Escherichia coli, the commonest cause of urinary tract infections. " 10/01/1987 - "The purpose of this study was to compare virulence factors and antibiotic resistance profiles of Escherichia coli strains isolated from dogs and humans with urinary tract infections. " Order ALL the reference details at left...
3.	Dental Caries (White Spot) 02/28/2010 - "Thus, attempts to control the development of dental caries only by inhibiting one of the several virulence factors are not effective. " 12/01/2005 - "The aim of this research is to identify and characterize genes that are responsible for observed virulence factors in Streptococcus mutans, which is the primary pathogen involved in the development of dental caries. " 01/01/1996 - "The enzyme activities studied are important elements in the pathophysiology of dental caries and may even be addressed as virulence factors." 01/01/1993 - "The introduction of molecular genetic approaches for characterizing these factors has led not only to a clearer understanding of the role of these virulence factors in cariogenicity but has also suggested some novel approaches for reducing further the incidence of dental caries." 03/01/1984 - "Virulence factors of Streptococcus mutans and dental caries prevention." Order ALL the reference details at left...
4.	Periodontal Diseases (Periodontal Disease) 01/01/1991 - "However, concrete evidence is not yet available that indicates that complement activation occurs in human periodontal disease and is important in either its pathogenesis or in protection against bacterial virulence factors." 01/01/2010 - "The virulence factors of Candida spp. increase host susceptibility to proliferation of these microorganisms and are likely to be important in the study of periodontal disease. " 01/01/2010 - "Herein, we briefly review the literature pertaining to the role of Candida spp. in periodontal disease, and consider the main virulence factors, the host immune response to these microorganisms, and the effect of concomitant immunosuppressive conditions." 09/01/2004 - "BACKGROUND: Both the virulence factors of periodontopathic bacteria and the immune response against them have been involved in tissue destruction observed in periodontal disease. " 10/01/2000 - "Such species namely Gram-negative, associated with the outbreak of periodontal disease have in common the capacity to disrupt the integrity of the host defences by means of the so called virulence factors. " Order ALL the reference details at left...
5.	Bacterial Infections (Bacterial Infection) 01/01/2004 - "The acquisition of knowledge about PAI, their structure, their mobility, and the pathogenicity factors they encode not only is helpful in gaining a better understanding of bacterial evolution and interactions of pathogens with eukaryotic host cells but also may have important practical implications such as providing delivery systems for vaccination, tools for cell biology, and tools for the development of new strategies for therapy of bacterial infections." 07/15/2003 - "In the present study, we detected the presence of several genes encoding for putative virulence factors and phenotypic activities that may play an important role in bacterial infection. " 02/01/1994 - "As in vitro studies have shown, gastroenteritic salmonellae seem to possess a number of so-called virulence factors that help them to evade the host's defenses against bacterial infection. " 01/01/1991 - "Studies on the molecular structure and immunological properties of pneumococcal virulence factors have provided general knowledge for the chemical basis of immunogenicity and prevention of bacterial infection. " 07/01/2009 - "Together these data show how Drosophila embryos can be used to track bacterial infection in real time and how mutant analysis can be used to genetically dissect the effects of specific bacterial virulence factors." Order ALL the reference details at left...

Related Drugs and Biologics

1.	Vaccines
2.	Proteins (Proteins, Gene)
3.	Antigens
4.	Integration Host Factors (Host Factor)
5.	Antibodies
6.	DNA (Deoxyribonucleic Acid)
7.	Bacterial Capsules
8.	Penicillins (Penicillin)
9.	Gram's stain
10.	Immunoglobulin A (IgA)

Related Therapies and Procedures

1.	Blood Transfusion (Blood Transfusions)
2.	Therapeutics
3.	Immunotherapy
4.	Stents
5.	Homologous Transplantation (Allograft)

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