Effect of Structured Physical Activity on Inflammation and Immune Activation Profile of Antiretroviral Therapy-Experienced Children Living With HIV.

Abstract

AIM:

To compare the markers of inflammation and immune activation in virally suppressed HIV-infected children on antiretroviral therapy, who practiced regular structured exercise comprising running and yoga to those who did not over a 2-year period.

METHODS:

This retrospective cohort study included 72 children aged 8 to 16 years divided into 2 groups, exercisers (n = 36) and the nonexercisers (n = 36) based on their intentional physical activity. The analyses were carried out at baseline and after 2 years (Y2) for the soluble biomarkers of inflammation and immune activation (tumor necrosis factor alpha, interleukin-6, interleukin-10, interferon gamma, sCD14, and sCD163). In addition, cell-associated biomarker (CD38), lipopolysaccharides, and the gene expression of interleukin-2 and brain-derived neurotrophic factor were also measured at Y2.

RESULTS:

Reduction in levels of sCD14 (effect size [ES], -0.6; 95% confidence interval [CI], -1.08 to -0.14), tumor necrosis factor alpha (ES, -0.7; 95% CI, -1.18 to -0.23), interferon gamma (ES, -0.7; 95% CI, -1.17 to -0.22), and interleukin-10 (ES, -0.6; 95% CI, -1.08 to -0.14) was observed among exercisers as compared with nonexercisers at Y2. In addition, CD38+ expressing CD4+ T cells were found to be lower among exercisers (P = .01) at Y2. However, the differences in levels of interleukin-6, sCD163, lipopolysaccharides, interleukin-2, and brain-derived neurotrophic factor were not significantly different among the 2 groups.

CONCLUSION:

The study result suggests that regular structured physical activity improves the inflammatory profile of antiretroviral therapy-treated HIV-infected children.

• Authors: Bindu P Gopalan, Mary Dias, Karthika Arumugam, Reena R D'Souza, Mathew Perumpil, Prasanna Kulkarni, Udaykumar Ranga, Anita Shet
• Journal: Pediatric exercise science (Pediatr Exerc Sci) Vol. 32 Issue 2 Pg. 73-80 (05 01 2020) ISSN: 1543-2920 [Electronic] United States
• PMID: 31881531 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-HIV Agents
• Biomarkers
• Cytokines

Topics

• Adolescent
• Anti-HIV Agents (therapeutic use)
• Biomarkers (blood)
• CD4-Positive T-Lymphocytes (cytology)
• Child
• Cytokines (blood)
• Exercise
• Female
• HIV Infections (drug therapy, immunology)
• Humans
• India
• Inflammation (blood, diagnosis)
• Male
• Retrospective Studies
• Running
• Yoga