Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: Albizia procera L. (Leguminosae) commonly known as Konda vagai in Tamil, is used for the treatment of stomach and intestinal disorders. A decoction of the bark is prescribed for rheumatism and haemorrhage. Traditionally, literature claims Albizia procera as a drug to have antirheumatic properties and hence used by Tribal for the management of chronic rheumatism. Consequently, the present study has been undertaken to illustrate the beneficial outcome of Albizia procera in adjuvant induced arthritic rat model with respect to its antioxidant and anti-inflammatory activities. AIM OF THE STUDY: The present study is aimed to investigate the oxidative stress and the expression of inflammatory markers in arthritic rats treated with ethanolic bark extract of Albizia procera. MATERIALS AND METHODS: RESULTS: HPTLC analysis showed the presence of 0.57% w/w of biochanin-A in ETBE. ETBE did not show any toxic signs up to 2000 mg/kg body weight. It exhibited the significant anti-inflammatory and antioxidant potential and did not show mortality up to 2000 mg/kg body weight. ETBE treatment significantly reduced the levels of TNF- α, IFN-α, IL-2, IL-6 and myeloperoxidase, and increased cathepsin D levels compared to vehicle treated animals. SOD, GSH and GPX levels were significantly restored to normal levels while LPO was significantly reduced at 200 mg/kg b. wt. Treated animals. Histopathological studies showed complete cartilage regeneration and near normal joint in ETBE treated arthritic rats. CONCLUSION:
ETBE demonstrated potent anti-inflammatory activity by modulating the expression of inflammatory cytokines and restoring the antioxidant enzyme levels.
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Authors | M Sangeetha, D Chamundeeswari, C Saravana Babu, C Rose, V Gopal |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 250
Pg. 112435
(Mar 25 2020)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 31785384
(Publication Type: Journal Article)
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Copyright | Copyright © 2019 Elsevier B.V. All rights reserved. |
Chemical References |
- Anti-Inflammatory Agents
- Antioxidants
- Biphenyl Compounds
- Cytokines
- Picrates
- Plant Extracts
- Solvents
- Nitric Oxide
- Ethanol
- 1,1-diphenyl-2-picrylhydrazyl
- Glutathione Peroxidase
- Superoxide Dismutase
- Glutathione
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Topics |
- Albizzia
- Animals
- Anti-Inflammatory Agents
(pharmacology, therapeutic use, toxicity)
- Antioxidants
(pharmacology, therapeutic use, toxicity)
- Arthritis, Experimental
(blood, drug therapy, genetics, pathology)
- Biphenyl Compounds
(chemistry)
- Cytokines
(blood, genetics)
- Ethanol
(chemistry)
- Female
- Glutathione
(blood)
- Glutathione Peroxidase
(blood)
- Joints
(drug effects, pathology)
- Lipid Peroxidation
(drug effects)
- Nitric Oxide
(chemistry)
- Oxidative Stress
(drug effects)
- Picrates
(chemistry)
- Plant Bark
(chemistry)
- Plant Extracts
(chemistry, pharmacology, therapeutic use, toxicity)
- Rats, Sprague-Dawley
- Solvents
(chemistry)
- Superoxide Dismutase
(blood)
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