Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: OBJECTIVE: METHODS: The subjects came from the 5C trial (chictr.org number: chictr-trc-07000021), post-PCI patients suffered from ACS with mild-to-moderate renal insufficiency (30 mL•min-1•1.73 m-2 < estimated glomerular filtration rate≤89 mL•min-1•1.73 m-2) included. The study population consisted of 215 subjects in the control group who were treated with western medicine standard therapy, and 211 subjects in the treatment group who were treated with Chinese herbal medicines (Fufang Chuanxiong Capsule and Xinyue Capsule) for 6 months on the basis of western medicine standard therapy. All were followed for 1 year. The primary endpoint included the composite of cardiac death, nonfatal recurrent myocardial infarction, and ischemia-driven revascularization. Secondary endpoint included the composite of stroke, congestive heart failure, and readmission for ACS. The serum creatinine and estimated glomerular filtration rate (eGFR) were evaluated. RESULTS: After 1 year follow-up of two groups, there were 16 cases of primary endpoint in the control group and 6 cases of primary endpoint in the treatment group [absolute risk reduction (ARR): 0.046, 95%CI: 0.004-0.088; relative risk (RR): 0.38, 95%CI: 0.15-0.96, P = 0.040]. There were 15 cases of secondary endpoint in the control group and 5 cases of secondary endpoint in the treatment (ARR: 0.041, 95%CI: 0.006-0.086; RR: 0.34, 95%CI: 0.13-0.92, P = 0.033). The eGFR in the treatment group was significantly higher than that in the control group (75.19 ± 16.74 mL min-1·1.73 m-2 VS 72.03 ± 14.96 mL min-1·1.73 m-2, P < 0.05). The eGFR in the treatment group was significantly higher after the intervention with Chinese herbal medicines than that before intervention (72.27 ± 11.83 mL min-1·1.73 m-2 VS 75.19 ± 16.74 mL min-1·1.73 m-2, P < 0.05). CONCLUSION:
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Authors | Da-Wu Zhang, Shao-Li Wang, Pei-Li Wang, Jian-Peng Du, Zhu-Ye Gao, Cheng-Long Wang, Hao Xu, Da-Zhuo Shi |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 248
Pg. 112354
(Feb 10 2020)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 31689480
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
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Copyright | Copyright © 2019 Elsevier B.V. All rights reserved. |
Chemical References |
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Topics |
- Acute Coronary Syndrome
(diagnostic imaging, mortality, therapy)
- Aged
- Cause of Death
- China
- Disease Progression
- Drugs, Chinese Herbal
(adverse effects, therapeutic use)
- Female
- Glomerular Filtration Rate
(drug effects)
- Humans
- Kidney
(drug effects, physiopathology)
- Male
- Middle Aged
- Percutaneous Coronary Intervention
(adverse effects, mortality)
- Recurrence
- Renal Insufficiency
(diagnosis, drug therapy, mortality, physiopathology)
- Risk Factors
- Severity of Illness Index
- Time Factors
- Treatment Outcome
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