Abstract | PURPOSE: METHODS: Using a retrospective cohort study design, we enrolled a sample of SCCPOCO patients treated in a Central German hospital over a 3-year period. The predictor variables: CPCs, were grouped into demographic, social, anatomic and prognostic. The main outcome variable was p16+. Appropriate statistics were computed, and P≤0.05 was considered statistically significant. RESULTS: Of 199 HNSCC patients, 23 had SCCPOCO and entered the analysis (mean age, 67±12 years; 4 females; 16 in stage I; 4 p16+; 22 underwent primary surgery). We found 8 cervical lymph node metastases (34.8%), 3 distant metastases (13%), 9 recurrences (30.1%) and 3 overall deaths (13%). With the exception of recurrence (P=0.006) and overall death (P=0.02), p16+ was not associated with predictor variables: young age, male gender, smoking, alcohol consumption, tumor location, TNM stages, time to recurrence, metastases, death from disease and survival of smokers (P>0.05). Primary brachytherapy failed to improve survival of p16+-SCCPOCO patients (P=0.04). CONCLUSIONS: The results of this study suggest that p16+- and p16--SCCPOCOs in Central Germany share similar CPCs, except recurrence and overall death. Upfront surgery with/without radio(chemo) therapy is recommended for all operable SCCPOCOs, regardless of HPV-status. Patients with p16+-SCCPOCOs require close follow-up. Future research should investigate the cause of these distinctive CPCs.
|
Authors | P Pitak-Arnnop, L-K Witohendro, J-P Meningaud, K Subbalekha, A Iamaroon, N Sirintawat, A Klaisiri, A Neff |
Journal | Journal of stomatology, oral and maxillofacial surgery
(J Stomatol Oral Maxillofac Surg)
Vol. 121
Issue 3
Pg. 213-218
(Jun 2020)
ISSN: 2468-7855 [Electronic] France |
PMID | 31676425
(Publication Type: Journal Article)
|
Copyright | Copyright © 2019 Elsevier Masson SAS. All rights reserved. |
Chemical References |
- Cyclin-Dependent Kinase Inhibitor p16
|
Topics |
- Aged
- Carcinoma, Squamous Cell
(diagnosis)
- Cyclin-Dependent Kinase Inhibitor p16
- Female
- Germany
(epidemiology)
- Head and Neck Neoplasms
- Humans
- Male
- Middle Aged
- Neoplasm Recurrence, Local
(therapy)
- Oropharynx
- Retrospective Studies
|