The effect of C-peptide on diabetic nephropathy: A review of molecular mechanisms.

Abstract

C-peptide is a small peptide connecting two chains of proinsulin molecule and is dissociated before the release of insulin. It is secreted in an equimolar amount to insulin from the pancreatic beta-cells into the circulation. Recent evidence demonstrates that it has other physiologic activities beyond its structural function. C-peptide modulates intracellular signaling pathways in various pathophysiologic states and, could potentially be a new therapeutic target for different disorders including diabetic complications. There is growing evidence that c-peptide has modulatory effects on the molecular mechanisms involved in the development of diabetic nephropathy. Although we have little direct evidence, pharmacological properties of c-peptide suggest that it can provide potent renoprotective effects especially, in a c-peptide deficient milieu as in type 1 diabetes mellitus. In this review, we describe possible molecular mechanisms by which c-peptide may improve renal efficiency in a diabetic milieu.

• Authors: Habib Yaribeygi, Mina Maleki, Thozhukat Sathyapalan, Amirhossein Sahebkar
• Journal: Life sciences (Life Sci) Vol. 237 Pg. 116950 (Nov 15 2019) ISSN: 1879-0631 [Electronic] Netherlands
• PMID: 31605709 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2019. Published by Elsevier Inc.

Chemical References

• C-Peptide

Topics

• Animals
• C-Peptide (therapeutic use)
• Diabetes Complications (etiology, prevention & control)
• Diabetes Mellitus, Type 1 (complications)
• Diabetic Nephropathies (etiology, prevention & control)
• Humans