Holothuria Leucospilota Polysaccharides Ameliorate Hyperlipidemia in High-Fat Diet-Induced Rats via Short-Chain Fatty Acids Production and Lipid Metabolism Regulation.

Abstract

Holothuria leucospilota polysaccharides (HLP) are expected to become potential resources for the treatment of hyperlipidemia because of their various bioactivities. In the study, the treatment of HLP on improving hyperlipidemia in rats was explored. Oral administration of HLP at 100 or 200 mg/kg body weight effectively alleviated serum lipid levels and liver histological abnormalities in high-fat-diet rats. HLP regulated abnormal mRNA, lipogenesis-related hormones and inflammatory cytokines (tumor necrosis factor-α, interleukin-6 and interleukin-12) levels. HLP improved the ability of gut microbiota to produce short-chain fatty acids (SCFAs). SCFAs have been found to ameliorate liver lesions. Therefore, HLP alleviated hyperlipidemia by improving the levels of SCFAs to regulate lipid metabolism. These results indicated that HLP could be used as beneficial polysaccharides to alleviate hyperlipidemia.

• Authors: Yiqiong Yuan, Qibing Liu, Fuqiang Zhao, Jun Cao, Xuanri Shen, Chuan Li
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 20 Issue 19 (Sep 24 2019) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 31554265 (Publication Type: Journal Article)

Chemical References

• Fatty Acids, Volatile
• Hormones
• Inflammation Mediators
• Lipids
• Polysaccharides

Topics

• Animals
• Diet, High-Fat (adverse effects)
• Disease Models, Animal
• Fatty Acids, Volatile (metabolism)
• Gastrointestinal Microbiome
• Holothuria (chemistry)
• Hormones (metabolism)
• Hyperlipidemias (drug therapy, etiology, metabolism)
• Inflammation Mediators
• Lipid Metabolism (drug effects)
• Lipids (blood)
• Liver (metabolism, pathology)
• Models, Biological
• Polysaccharides (chemistry, pharmacology)
• Rats