Interplay between the Mediterranean diet and C-reactive protein genetic polymorphisms towards inflammation in adolescents.

Abstract

AIM:

From a nutrigenetics perspective, we aim to investigate the moderating role of the Mediterranean diet and each of its subgroups in the association between C-reactive protein (CRP) gene polymorphisms and CRP blood concentration in adolescents.

METHODS:

In 562 adolescents (13-17 y) of the European HELENA study, data was available on circulating CRP levels as inflammatory biomarker, three CRP gene SNPs (rs3093068, rs1204, rs1130864), food intake determined by a self-administered computerized 24 h-dietary recall for 2 days, and body composition. A 9-point Mediterranean diet score and each food subgroup were tested as moderator via SNP*diet interaction. Analyzes were adjusted for age, sex, puberty, adiposity and socioeconomic status.

RESULTS:

The minor allele frequencies of rs3093068 and rs1130864 SNPs (GG and TT, respectively) were associated with higher CRP concentrations, while rs1205 (CT/TT) was associated with lower CRP concentrations. There were significant interactions between rs3093068 and Mediterranean diet (B = -0.1139, p = 0.011), or the fish food subgroup (B = -0.0090, p = 0.022), so that those with the highest genetic CRP risk underwent the highest CRP attenuation by a healthier diet. Although the effect of diet and SNP was substantial, the explained variance by interaction was only 1%.

CONCLUSION:

Greater adherence to the Mediterranean diet and particularly its fish component was associated with a lower CRP blood concentrations especially in those at highest genetic risk due to the rs3093068 SNP.

• Authors: Aline B Arouca, Aline Meirhaeghe, Jean Dallongeville, Luis A Moreno, Gustavo Jacob Lourenço, Ascensión Marcos, Inge Huybrechts, Yannis Manios, Christina-Paulina Lambrinou, Frederic Gottrand, Anthony Kafatos, Mathilde Kersting, Michael Sjöström, Kurt Widhalm, Marika Ferrari, Denes Molnár, Marcela González-Gross, Maria Forsner, Stefaan De Henauw, Nathalie Michels, HELENA Study Group
• Journal: Clinical nutrition (Edinburgh, Scotland) (Clin Nutr) Vol. 39 Issue 6 Pg. 1919-1926 (06 2020) ISSN: 1532-1983 [Electronic] England
• PMID: 31500937 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

Chemical References

• C-Reactive Protein

Topics

• Adolescent
• Age Factors
• Animals
• C-Reactive Protein (genetics)
• Cross-Sectional Studies
• Diet, Mediterranean
• Europe (epidemiology)
• Female
• Fishes
• Gene-Environment Interaction
• Genetic Predisposition to Disease
• Humans
• Inflammation (diagnosis, epidemiology, genetics, prevention & control)
• Male
• Nutrigenomics
• Nutritive Value
• Phenotype
• Polymorphism, Single Nucleotide
• Risk Assessment
• Risk Factors
• Seafood