Essential oil of Schisandra chinensis ameliorates cognitive decline in mice by alleviating inflammation.

Abstract

In this study, we aim to assess possible impacts of essential oil (SEO) from Schisandra chinensis (Turcz.) Baill. (S. chinensis) on mice with cognition impairment. Our data showed that SEO improved the cognitive ability of mice with Aβ1-42 or lipopolysaccharides (LPS)-induced Alzheimer's disease (AD) and suppressed the production of tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6), and interleukin-1β (IL-1β) in the hippocampus. Furthermore, SEO inhibited p38 activation, but had little effect on other signaling proteins in the MAPK family, such as extracellular signal-regulated kinase 1/2 (ERK1/2) and c-Jun N-terminal kinase 1/2 (JNK). The SEO and BV-2 microglia co-culture was performed to further confirm the anti-inflammatory activity of SEO. The data showed that SEO decreased nitric oxide (NO) levels in LPS-stimulated BV-2 microglia and significantly blocked LPS-induced MAPKs activation. Taken together, these findings suggested that SEO produces anti-AD effects on AD mice partly by modulating neuroinflammation through the NF-κB/MAPK signaling pathway.

• Authors: Mengjie Xu, Xiaoying Zhang, Fangyi Ren, Tingxu Yan, Bo Wu, Kaishun Bi, Wenchuan Bi, Ying Jia
• Journal: Food & function (Food Funct) Vol. 10 Issue 9 Pg. 5827-5842 (Sep 01 2019) ISSN: 2042-650X [Electronic] England
• PMID: 31463498 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Interleukin-1beta
• Interleukin-6
• NF-kappa B
• Oils, Volatile
• Plant Oils
• Tumor Necrosis Factor-alpha
• Nitric Oxide
• Mitogen-Activated Protein Kinase 3

Topics

• Alzheimer Disease (drug therapy, genetics, immunology, psychology)
• Animals
• Anti-Inflammatory Agents (administration & dosage)
• Cognition (drug effects)
• Humans
• Interleukin-1beta (genetics, immunology)
• Interleukin-6 (genetics, immunology)
• Male
• Mice
• Microglia (chemistry)
• Mitogen-Activated Protein Kinase 3 (genetics, immunology)
• NF-kappa B (genetics, immunology)
• Nitric Oxide (immunology)
• Oils, Volatile (administration & dosage)
• Plant Oils (administration & dosage)
• Schisandra (chemistry)
• Tumor Necrosis Factor-alpha (genetics, immunology)