Dieldrin is an environmental contaminant that adversely affects aquatic organisms. The data presented in this study are proteomic data collected in liver of zebrafish that were exposed to the
pesticide in a dietary exposure. For label free proteomics, data were collected with a quadrupole Time-of-Flight mass spectrometer and for iTRAQ proteomics, data were acquired using a hybrid quadrupole Orbitrap (Q Exactive) MS system. Using
formic acid digestion and label free proteomics, 2,061
proteins were identified, and among those, 103 were differentially abundant (p < 0.05 in at least one dose). In addition, iTRAQ proteomics identified 722
proteins in the liver of zebrafish following
dieldrin treatment. The label-free approach identified 21
proteins that followed a dose dependent response. Of the differentially abundant
proteins identified by iTRAQ, there were 26 unique expression patterns for
proteins based on the three doses of
dieldrin.
Proteins were queried for disease networks to learn more about adverse effects in the liver following
dieldrin exposure. Differentially abundant
proteins were related to
metabolic disease,
steatohepatitis and
lipid metabolism disorders,
drug-induced liver injury,
neoplasms, tissue degeneration and liver
metastasis. The proteomics data described here is associated with a research article, "Label-free and iTRAQ proteomics analysis in the liver of zebrafish (Danio rerio) following a dietary exposure to the organochlorine
pesticide dieldrin" (Simmons et al. 2019). This investigation reveals new
biomarkers of toxicity and will be of interest to those studying aquatic toxicology and pesticides.