Abstract | BACKGROUND: METHODS: This was a retrospective study of septic AKI patients who underwent RRT in a Chinese university hospital. All enrolled patients tested PCT and NT-proBNP at RRT initiation. PCT and NT-proBNP levels were compared between the survivors and non-survivors. Receiver operating characteristic (ROC) curves of the 2 biomarkers were performed for predicting in-hospital mortality. According to the median value of PCT (16.2 ng/mL) and NT-proBNP (10,271 pg/mL), patients were divided into 4 groups (low PCT and low NT-proBNP; high PCT and low NT-proBNP; low PCT and high NT-proBNP; high PCT and high NT-proBNP). The Kaplan-Meier survival curves were used to analyze the 28-day survival rate in the 4 groups. RESULTS: A total of 81 patients were enrolled in the study. Of which, 48 (59.3%) patients died during hospitalization. The median of NT-proBNP in non-survivors was significantly higher than in survivors (p = 0.001), while PCT had no significant difference (p = 0.412). The area under the ROC curve of PCT and NT-proBNP for predicting in-hospital mortality was 0.561 (95% CI 0.426-0.695) and 0.729 (95% CI 0.604-0.854). Kaplan-Meier survival curve analysis showed that increased NT-proBNP level was associated with 28-day mortality while combined with PCT there was no statistical difference in 4 different level groups. CONCLUSION:
NT-proBNP has a certain predictive value for the prognosis in septic AKI patients who received RRT. It seems that the initial PCT value for prognosis is limited. The combination of PCT and - NT-proBNP to evaluate the prognosis in these critically ill patients is currently unclear.
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Authors | Xiaohua Sheng, Jingye Yang, Gang Yu, Yang Fei, Hongda Bao, Jianyong Yin, Weifeng Huang, Zebo Tian, Niansong Wang, Claudio Ronco |
Journal | Blood purification
(Blood Purif)
Vol. 48
Issue 3
Pg. 262-271
( 2019)
ISSN: 1421-9735 [Electronic] Switzerland |
PMID | 31311006
(Publication Type: Journal Article)
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Copyright | © 2019 S. Karger AG, Basel. |
Chemical References |
- Peptide Fragments
- Procalcitonin
- pro-brain natriuretic peptide (1-76)
- Natriuretic Peptide, Brain
|
Topics |
- Acute Kidney Injury
(blood, complications, diagnosis, mortality)
- Adult
- Aged
- Female
- Hospital Mortality
- Humans
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Natriuretic Peptide, Brain
(blood)
- Peptide Fragments
(blood)
- Procalcitonin
(blood)
- Prognosis
- ROC Curve
- Renal Replacement Therapy
- Sepsis
(complications)
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