High level of soluble human leukocyte antigen (HLA)-G at beginning of pregnancy as predictor of risk of malaria during infancy.

Abstract

Placental malaria has been associated with an immune tolerance phenomenon and a higher susceptibility to malaria infection during infancy. HLA-G is involved in fetal maternal immune tolerance by inhibiting maternal immunity. During infections HLA-G can be involved in immune escape of pathogens by creating a tolerogenic environment. Recent studies have shown an association between the risk of malaria and HLA-G at both genetic and protein levels. Moreover, women with placental malaria have a higher probability of giving birth to children exhibiting high sHLA-G, independently of their own level during pregnancy. Our aim was to explore the association between the level of maternal soluble HLA-G and the risk of malaria infection in their newborns. Here, 400 pregnant women and their children were actively followed-up during 24 months. The results show a significant association between the level of sHLA-G at the first antenatal visit and the time to first malaria infection during infancy adjusted to the risk of exposure to vector bites (aHR = 1.02, 95%CI [1.01-1.03], p = 0.014). The level of sHLA-G is a significant predictor of the occurrence of malaria infection during infancy consistent with the hypothesis that mother sHLA-G could be a biomarker of malaria susceptibility in children.

• Authors: Tania C d'Almeida, Ibrahim Sadissou, Mermoz Sagbohan, Jacqueline Milet, Euripide Avokpaho, Laure Gineau, Audrey Sabbagh, Kabirou Moutairou, Eduardo A Donadi, Benoit Favier, Cédric Pennetier, Thierry Baldet, Nicolas Moiroux, Edgardo Carosella, Philippe Moreau, Nathalie Rouas-Freiss, Gilles Cottrell, David Courtin, André Garcia
• Journal: Scientific reports (Sci Rep) Vol. 9 Issue 1 Pg. 9160 (06 24 2019) ISSN: 2045-2322 [Electronic] England
• PMID: 31235762 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HLA-G Antigens

Topics

• Adult
• Female
• HLA-G Antigens (chemistry, metabolism)
• Humans
• Infant
• Malaria (epidemiology)
• Male
• Pregnancy
• Proportional Hazards Models
• Risk Assessment
• Solubility