The effect of acupuncture on the expression of inflammatory factors TNF-α, IL-6,IL-1 and CRP in cerebral infarction: A protocol of systematic review and meta-analysis.

Abstract

BACKGROUND:

The mechanisms of acupuncture on the treatment of cerebral infarction remain unclear, the aim of the present study was to provides a protocol of systematic review and meta-analysis, with which we will collect clinical evidence to verify whether acupuncture will have an effect on reducing the levels of tumor necrosis factor α (TNF-α), C-reactive protein (CRP), interleukin-1 (IL-1), and interleukin (IL-6) after cerebral infarction based on evidence-based studies.

METHODS:

Included studies will be retrieved according to inclusion and exclusion criteria from 5 English databases (the MEDLINE via PubMed, the Cochrane Library, Embase, the Web of Science, and Ovid database), and 4 Chinese databases (China Science and Technology Journal Database (VIP), Chinese Biomedical Literature Database (CBM), Wan-fang Database, China National Knowledge Infrastructure (CNKI)) from October 1990 to October 2017. The inflammatory factor levels of TNF-α and IL-1,IL-6,CRP will be marked as major outcomes. We will use RevMan V.5.3 software to calculate the data synthesis and will conduct meta-analysis based on the collected data.

RESULTS:

The inflammatory factor levels of TNF-α and IL-1,IL-6,CRP, mortality and adverse effects will be measured and comprehensively assessed to evaluate the adjunctive effect of XBP on CHF from this systematic review and meta-analysis with current clinical evidence.

CONCLUSION:

The systematic review and meta-analysis will assess the effect of acupuncture on the expression of inflammatory factors TNF-α, IL-6, IL-1 and CRP in cerebral infarction with up-to-date clinical evidence.

PROSPERO REGISTRATION NUMBER:

PROSPERO CRD42017078583.

• Authors: Yuru Chen, Wei Huang, Zunjiang Li, Yunbiao Duan, Zhaoxiong Liang, Hong Zhou, Chuyue Tang
• Journal: Medicine (Medicine (Baltimore)) Vol. 98 Issue 24 Pg. e15408 (Jun 2019) ISSN: 1536-5964 [Electronic] United States
• PMID: 31192907 (Publication Type: Journal Article)

Chemical References

• IL6 protein, human
• Interleukin-1
• Interleukin-6
• TNF protein, human
• Tumor Necrosis Factor-alpha
• C-Reactive Protein

Topics

• Acupuncture Therapy (methods)
• C-Reactive Protein (metabolism)
• Cerebral Infarction (immunology, therapy)
• China
• Data Collection
• Gene Expression Regulation
• Humans
• Interleukin-1 (metabolism)
• Interleukin-6 (metabolism)
• Middle Aged
• Randomized Controlled Trials as Topic
• Research Design
• Software
• Treatment Outcome
• Tumor Necrosis Factor-alpha (metabolism)
• Meta-Analysis as Topic
• Systematic Review as Topic