Charcot-Leyden crystal protein/galectin-10 is a surrogate biomarker of eosinophilic airway inflammation in asthma.

Abstract

Aim: Eosinophilic asthma is associated with more exacerbations and differential responses to treatment. The aim of this study was to assess if CLC/Gal-10 and MBP-1 are surrogate biomarkers of eosinophilic inflammation in asthma. Methods & results: Sputum induction was performed in patients with asthma and in healthy controls. Sputum analysis revealed higher (p < 0.001) levels of CLC/Gal-10 and MBP-1 in asthmatics versus healthy controls. CLC/Gal-10 levels were highly correlated (rs = 0.74; p < 0.001) with sputum eosinophils; MBP-1 approached significance (r = 0.44; p = 0.07). Conclusion: Increased CLC/Gal-10 and MBP-1 levels in the sputum were strongly correlated with sputum eosinophils in patients with asthma. CLC/Gal-10 and MBP-1 may be useful biomarkers for differentiation of eosinophilic airway inflammation in asthma.

• Authors: Sharmilee M Nyenhuis, Preeth Alumkal, Jian Du, Brian T Maybruck, Mark Vinicky, Steven J Ackerman
• Journal: Biomarkers in medicine (Biomark Med) Vol. 13 Issue 9 Pg. 715-724 (06 2019) ISSN: 1752-0371 [Electronic] England
• PMID: 31157540 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• DENND4A protein, human
• DNA-Binding Proteins
• Galectins
• Glycoproteins
• galectin 10, human
• Lysophospholipase
• lysolecithin acylhydrolase

Topics

• Adult
• Asthma (metabolism, pathology)
• Biomarkers (analysis)
• Case-Control Studies
• DNA-Binding Proteins (analysis, metabolism)
• Enzyme-Linked Immunosorbent Assay (methods)
• Eosinophilia (metabolism, pathology)
• Eosinophils (pathology)
• Feasibility Studies
• Female
• Galectins (analysis, metabolism)
• Glycoproteins (analysis, metabolism)
• Humans
• Inflammation (metabolism, pathology)
• Lysophospholipase (analysis, metabolism)
• Male
• Middle Aged
• Pilot Projects
• Sputum (cytology, metabolism)
• Young Adult