Abstract | BACKGROUND: Alcohol-related liver disease is one of the most prevalent chronic liver diseases worldwide. Mechanisms involved in the pathogenesis of alcohol-related liver disease are not well understood. Oxylipins play a crucial role in numerous biological processes and pathological conditions. Nevertheless, oxylipins are not well studied in alcohol-related liver disease. AIMS: METHODS: RESULTS: Our results show profound alterations in the serum oxylipin profile of patients with alcohol use disorder and alcoholic hepatitis compared to nonalcoholic controls. Spearman correlation of the oxylipins with clinical parameters shows a link between different serum oxylipins and intestinal permeability, aspartate aminotransferase, bilirubin, albumin, international normalized ratio, platelet count, steatosis, fibrosis and model for end-stage liver disease score. Especially, higher level of serum 20-HETE was significantly associated with decreased albumin, increased hepatic steatosis, polymorphonuclear infiltration, and 90-day mortality. CONCLUSIONS:
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Authors | Bei Gao, Sonja Lang, Yi Duan, Yanhan Wang, Debbie L Shawcross, Alexandre Louvet, Philippe Mathurin, Samuel B Ho, Peter Stärkel, Bernd Schnabl |
Journal | Digestive diseases and sciences
(Dig Dis Sci)
Vol. 64
Issue 7
Pg. 1878-1892
(07 2019)
ISSN: 1573-2568 [Electronic] United States |
PMID | 31076986
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Biomarkers
- Fatty Acids, Omega-3
- Fatty Acids, Omega-6
- Oxylipins
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Topics |
- Adult
- Aged
- Alcoholism
(blood, diagnosis)
- Biomarkers
(blood)
- Chromatography, High Pressure Liquid
- Chromatography, Reverse-Phase
- Fatty Acids, Omega-3
(blood)
- Fatty Acids, Omega-6
(blood)
- Feces
(chemistry)
- Female
- Hepatitis, Alcoholic
(blood, diagnosis)
- Humans
- Male
- Metabolomics
(methods)
- Middle Aged
- Oxylipins
(blood)
- Spectrometry, Mass, Electrospray Ionization
- Tandem Mass Spectrometry
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