Oxysterol research: a brief review.

Abstract

In the present study, we discuss the recent developments in oxysterol research. Exciting results have been reported relating to the involvement of oxysterols in the fields of neurodegenerative disease, especially in Huntington's disease, Parkinson's disease and Alzheimer's disease; in signalling and development, in particular, in relation to Hedgehog signalling; and in cancer, with a special focus on (25R)26-hydroxycholesterol. Methods for the measurement of oxysterols, essential for understanding their mechanism of action in vivo, and valuable for diagnosing rare diseases of cholesterol biosynthesis and metabolism are briefly considered.

• Authors: William J Griffiths, Yuqin Wang
• Journal: Biochemical Society transactions (Biochem Soc Trans) Vol. 47 Issue 2 Pg. 517-526 (04 30 2019) ISSN: 1470-8752 [Electronic] England
• PMID: 30936243 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: © 2019 The Author(s).

Chemical References

• Oxysterols
• Sterols
• Cytochrome P-450 Enzyme System
• Cholesterol

Topics

• Animals
• Cholesterol (metabolism)
• Cytochrome P-450 Enzyme System (metabolism)
• Humans
• Huntington Disease (metabolism)
• Oxysterols (metabolism)
• Sterols (metabolism)