Abstract |
We describe the case of 50-year-old female patient who presented with severe gastrointestinal symptoms and progressive weight loss of unknown origin. Shortly after admission, she developed an acute flare of thrombotic thrombocytopaenic purpura ( TTP) that had to be treated by plasma exchange therapy and rituximab administration. While the signs of TTP subsided, the gastrointestinal symptoms worsened with abdominal cramps, massive gastric retention, malnourishment and a stenosis due to extensive inflammation and wall thickening of the small bowel. Extensive diagnostic efforts yielded no specific cause, so the patient-based on the histopathological findings-was diagnosed with idiopathic non-granulomatous ulcerative jejunoileitis. Following a highly complicated clinical course over several months, successful remission of the inflammatory activity and recovery of the patient could be obtained by TNF-alpha blockade.
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Authors | Fabian Braun, Victor Suarez, Johanna Dinter, Stefan Haneder, Alexander Quaas, Thomas Benzing, Dirk Nierhoff, Roman-Ulrich Müller |
Journal | BMJ open gastroenterology
(BMJ Open Gastroenterol)
Vol. 6
Issue 1
Pg. e000252
( 2019)
ISSN: 2054-4774 [Print] England |
PMID | 30899536
(Publication Type: Journal Article)
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