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Inhibition of dextran sodium sulfate-induced colitis in mice by baker's yeast polysaccharides.

Abstract
Most of the reported yeast polysaccharides are a mixture of chitin, β-glucan and mannoprotein, leading to different biological activities. Herein, we report the structures and the anti-inflammation of the purified baker's yeast polysaccharides (BBG1-BBG4). Experimental data indicated that BBG1 was a highly branched β-(1,6)-glucan linked to mannoprotein; BBG2 was a linear β-(1,3)-glucan; BBG3 and BBG4 were mixtures of a β-(1,6)-branched β-(1,3)-glucan and a linear β-(1,3)-glucan. Of these, BBG1 exhibited stronger inhibition of pro-inflammatory mediators of NO/iNOS, IL-6, IL-1β, etc. at protein and/or mRNA levels in LPS-stimulated RAW264.7 cells through inhibiting MAPK signalling pathways. Orally administered BBG1 and BBG2 significantly decreased the pro-inflammatory mediators of IL-6, iNOS and IL-1β at protein and/or mRNA levels, as well as colonic mucosal damage and macrophages infiltration in DSS-induced colitis mice. All these findings suggest that yeast polysaccharides have potentials as anti-inflammatory drugs or adjuvants in the intestinal inflammation therapy.
AuthorsYing Sun, Xiaodan Shi, Xing Zheng, Shaoping Nie, Xiaojuan Xu
JournalCarbohydrate polymers (Carbohydr Polym) Vol. 207 Pg. 371-381 (Mar 01 2019) ISSN: 1879-1344 [Electronic] England
PMID30600019 (Publication Type: Journal Article)
CopyrightCopyright © 2018. Published by Elsevier Ltd.
Chemical References
  • Anti-Inflammatory Agents
  • Cytokines
  • beta-Glucans
  • Dextran Sulfate
Topics
  • Administration, Oral
  • Animals
  • Anti-Inflammatory Agents (administration & dosage, therapeutic use)
  • Colitis (chemically induced, drug therapy)
  • Cytokines (metabolism)
  • Dextran Sulfate
  • Inflammation (chemically induced, drug therapy)
  • Intestinal Mucosa (metabolism)
  • MAP Kinase Signaling System (drug effects)
  • Male
  • Mice
  • Mice, Inbred C57BL
  • RAW 264.7 Cells
  • Saccharomyces cerevisiae (chemistry)
  • beta-Glucans (administration & dosage, therapeutic use)

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