Abstract |
Most of the reported yeast polysaccharides are a mixture of chitin, β- glucan and mannoprotein, leading to different biological activities. Herein, we report the structures and the anti- inflammation of the purified baker's yeast polysaccharides (BBG1-BBG4). Experimental data indicated that BBG1 was a highly branched β-(1,6)-glucan linked to mannoprotein; BBG2 was a linear β-(1,3)- glucan; BBG3 and BBG4 were mixtures of a β-(1,6)-branched β-(1,3)-glucan and a linear β-(1,3)-glucan. Of these, BBG1 exhibited stronger inhibition of pro-inflammatory mediators of NO/iNOS, IL-6, IL-1β, etc. at protein and/or mRNA levels in LPS-stimulated RAW264.7 cells through inhibiting MAPK signalling pathways. Orally administered BBG1 and BBG2 significantly decreased the pro-inflammatory mediators of IL-6, iNOS and IL-1β at protein and/or mRNA levels, as well as colonic mucosal damage and macrophages infiltration in DSS-induced colitis mice. All these findings suggest that yeast polysaccharides have potentials as anti-inflammatory drugs or adjuvants in the intestinal inflammation therapy.
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Authors | Ying Sun, Xiaodan Shi, Xing Zheng, Shaoping Nie, Xiaojuan Xu |
Journal | Carbohydrate polymers
(Carbohydr Polym)
Vol. 207
Pg. 371-381
(Mar 01 2019)
ISSN: 1879-1344 [Electronic] England |
PMID | 30600019
(Publication Type: Journal Article)
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Copyright | Copyright © 2018. Published by Elsevier Ltd. |
Chemical References |
- Anti-Inflammatory Agents
- Cytokines
- beta-Glucans
- Dextran Sulfate
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Topics |
- Administration, Oral
- Animals
- Anti-Inflammatory Agents
(administration & dosage, therapeutic use)
- Colitis
(chemically induced, drug therapy)
- Cytokines
(metabolism)
- Dextran Sulfate
- Inflammation
(chemically induced, drug therapy)
- Intestinal Mucosa
(metabolism)
- MAP Kinase Signaling System
(drug effects)
- Male
- Mice
- Mice, Inbred C57BL
- RAW 264.7 Cells
- Saccharomyces cerevisiae
(chemistry)
- beta-Glucans
(administration & dosage, therapeutic use)
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