Abstract | BACKGROUND: OBJECTIVES: To compare the evolution of liver parameters after SG and RYGB and their relationships with improvement of metabolic disorders. METHODS: Metabolic parameters and abdominal ultrasonography were recorded before and 1 year after bariatric surgery in all patients who underwent SG or RYGB between 2004 and 2016 in our institution. SETTING: University hospital, Colombes, France. RESULTS: Five hundred thirty-three patients (15% men, age 43 ± 11 yr) were analyzed, including 326 who underwent RYGB and 207 who underwent SG. Before surgery, body mass index (44.7 ± 5.7 versus 44.4 ± 7.4 kg/m²) and metabolic parameters were not significantly different. One year after surgery, RYGB induced greater weight loss (31.9 ± 7.7 versus 28.6 ± 8.3 %, P < .001). Metabolic parameters improved in both groups, but fasting insulin, low-density lipoprotein cholesterol, C-reactive protein, and ferritin were lower after RYGB (P < .001). In contrast, transaminases were higher after RYGB compared with SG ( alanine aminotransferase: 31.6 ± 18.7 versus 22.6 ± 7.7 IU/L; P < .001). The persistence of alanine aminotransferase >34 IU/L (27% versus 7% of patients, P < .001) was independent of the persistence of steatosis on ultrasonography (39% versus 37% of patients) 1 year after RYGB and SG, respectively. CONCLUSION: Despite a greater improvement of metabolic disorders, RYGB has less beneficial effect on liver parameters compared with SG. Further studies are required to define the mechanisms explaining these differences between both procedures.
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Authors | Séverine Ledoux, Ouidad Sami, Daniela Calabrese, Maud Le Gall, Martin Flamant, Muriel Coupaye |
Journal | Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
(Surg Obes Relat Dis)
Vol. 15
Issue 2
Pg. 220-226
(02 2019)
ISSN: 1878-7533 [Electronic] United States |
PMID | 30598254
(Publication Type: Comparative Study, Journal Article)
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Copyright | Copyright © 2018 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved. |
Topics |
- Adult
- Body Mass Index
- Female
- France
- Gastrectomy
- Gastric Bypass
- Humans
- Liver Function Tests
- Male
- Metabolic Diseases
(etiology, prevention & control)
- Middle Aged
- Obesity, Morbid
(complications, surgery)
- Retrospective Studies
- Treatment Outcome
- Weight Loss
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