Scheduled Intravenous Acetaminophen for Postoperative Management of Patients Who Had Thoracoscopic Esophagectomy for Esophageal Cancer.

Abstract

BACKGROUND/AIM:

The aim of this study was to assess the effects of scheduled intravenous acetaminophen for postoperative management of patients who underwent thoracoscopic esophagectomy for esophageal cancer.

PATIENTS AND METHODS:

The records of 56 consecutive patients who underwent thoracoscopic esophagectomy in the prone position for esophageal cancer were reviewed. For postoperative pain control, twenty-eight patients underwent the scheduled intravenous acetaminophen (SIVA group), whereas the other 28 were managed with intravenous flurbiprofen (Control group). The perioperative outcomes of the two groups were compared.

RESULTS:

The incidence of pneumonia and the total numerical rating scale of postoperative pain level were significantly lower in the SIVA group than in the Control group (3.6% vs. 25.0%; p=0.022, 40 vs. 93; p=0.027). Patients' fever on the third day after surgery in the SIVA group was significantly lower than in the Control group (36.9°C vs. 37.2°C; p=0.029). However, the incidence of anastomotic leakage, laryngeal nerve palsy, the changes of postoperative C-reactive protein level, and the duration of hospital stay were not different between the two groups.

CONCLUSION:

Scheduled intravenous acetaminophen after thoracoscopic esophagectomy in patients with esophageal cancer was a useful strategy in reducing the incidence of postoperative pneumonia.

• Authors: Hiroyuki Kitagawa, Tsutomu Namikawa, Jun Iwabu, Sunao Uemura, Masaya Munekage, Sachi Tsuda, Keiichiro Yokota, Michiya Kobayashi, Kazuhiro Hanazaki
• Journal: Anticancer research (Anticancer Res) Vol. 39 Issue 1 Pg. 467-470 (Jan 2019) ISSN: 1791-7530 [Electronic] Greece
• PMID: 30591496 (Publication Type: Journal Article)
• Copyright: Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• Acetaminophen

Topics

• Acetaminophen (administration & dosage)
• Administration, Intravenous
• Aged
• Esophageal Neoplasms (complications, physiopathology, surgery)
• Esophagectomy (adverse effects)
• Female
• Humans
• Male
• Middle Aged
• Pain, Postoperative (drug therapy, physiopathology)
• Patient Positioning
• Pneumonia (drug therapy, etiology, physiopathology)
• Thoracoscopy (adverse effects)