Postoperative Pain

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6166 relevant articles (809 outcomes, 1096 trials/studies) found for this Disease

Description: Pain during the period after surgery.

Also Known As:

Pain, Postoperative; Postoperative Pains

Relationship Network

Disease Context: Research Results

Signs and Symptoms Pathological Conditions

Pathologic Processes: 2442

Postoperative Complications

Postoperative Pain: 6166

Signs and Symptoms

Pain: 74723

Postoperative Pain: 6166

Related Diseases

1.	Pain (Aches)
2.	Wounds and Injuries (Trauma)
3.	Vomiting
4.	Nausea
5.	Hemorrhage

Experts

1.	Moore, R A: 15 articles (01/2007 - 01/2000)
2.	McQuay, H J: 13 articles (01/2005 - 01/2000)
3.	Edwards, J E: 9 articles (01/2004 - 01/2000)
4.	Edwards, J: 7 articles (01/2005 - 01/2000)
5.	Dahl, J B: 5 articles (10/2008 - 02/2000)
6.	Turan, Alparslan: 5 articles (09/2008 - 04/2004)
7.	Barden, J: 5 articles (01/2005 - 01/2003)
8.	White, Paul F: 4 articles (09/2008 - 06/2003)
9.	Flood, Pamela: 4 articles (09/2008 - 12/2004)
10.	Viscusi, Eugene R: 4 articles (11/2007 - 03/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Postoperative Pain:

1.	Morphine (MS Contin)FDA LinkGeneric 06/01/1990 - "Epidural morphine is effective in the treatment of postoperative pain, but the incidence of associated side effects is high. " 01/01/2005 - "In contrast, intra-articular morphine does appear to be effective for decreasing postoperative pain." 05/01/1999 - "BACKGROUND AND OBJECTIVES: Morphine and nonsteroidal antiinflammatory drugs (NSAID) have been found to be effective in relieving postoperative pain. " 09/01/1991 - "We conclude that postoperative pain can be safely and effectively treated with epidural morphine on surgical wards." 04/01/1990 - "In conclusion, epidural catheters placed via the caudal approach are a safe and effective means of providing postoperative pain control in infants using preservative-free morphine. " Order ALL the reference details at left...
2.	Bupivacaine (Bupivacaine Hydrochloride)FDA LinkGeneric 11/01/2005 - "A total of 154 patients had good postoperative pain relief for 72 h with continuous infusion of 0.05% bupivacaine. " 11/01/2003 - "Patient satisfaction with postoperative pain management (95 +/- 3 versus 77 +/- 13) and quality of recovery (96 +/- 7 versus 83 +/- 14) was significantly improved in the bupivacaine group (versus control). " 01/01/1999 - "bupivacaine, both produced equally good postoperative pain control and allowed a significant reduction of analgesic requirement after knee arthroscopy." 02/01/1997 - "Although the literature shows certain controversy as to the effects of similar methods, our study concludes that instillation of a long-acting anesthetic, such as bupivacaine, into the subdiaphragmatic space after laparoscopic procedures is effective in postoperative pain reduction." 01/01/2005 - "Bupivacaine injection via these catheters in two cases was effective for reducing postoperative pain. " Order ALL the reference details at left...
3.	KetorolacIBA 08/01/1997 - "CONCLUSIONS: Although it is possible to demonstrate an improvement in early postoperative pain scores with intraoperative ketorolac and better overall ratings of ketorolac both intraoperatively and postoperatively as compared with placebo, the lack of clinically significant differences in analgesic efficacy in the two active study groups indicates the need for a careful consideration by the clinician of the risks versus benefits involved in the administration of antiplatelet medication in the perioperative period." 03/01/1994 - "Thus, perioperative ketorolac infusion improved the quality of postoperative pain relief, and had no major influence on endocrine-metabolic response and no negative influences on hemostatic and renal functions. " 01/01/1990 - "Intravenous ketorolac is effective for the treatment of postoperative pain." 05/01/1987 - "This study shows ketorolac to be a safe and effective analgesic for relief of postoperative pain." 02/01/1994 - "Ketorolac, when administered intramuscularly or orally, is a safe and effective analgesic agent for the short-term management of acute postoperative pain and can be used as an alternative to opioid therapy." Order ALL the reference details at left...
4.	Acetaminophen (Paracetamol)FDA LinkGeneric 05/01/2006 - "CONCLUSION: The analgesic efficacy of a 2 g starting dose of IV paracetamol was superior over the recommended dose of 1g in terms of magnitude and duration of analgesic effect for postoperative pain following third molar surgery, with no significant difference between groups regarding safety." 01/01/2004 - "A prior Cochrane systematic review concluded that paracetamol is also effective for postoperative pain, but additional trials have since been published. " 06/01/2009 - "Rectal acetaminophen has been used effectively for postoperative pain management in small children. " 01/01/1993 - "It is the purpose of this study to assess the efficacy of preoperative administration of acetaminophen on the prevalence of postoperative pain-related behaviors and the frequency of postoperative analgesic use in 4- to 10-year-old children following various dental procedures. " 01/01/2008 - "OBJECTIVES: To assess the efficacy of single dose oral paracetamol for the treatment of acute postoperative pain. " Order ALL the reference details at left...
5.	Fentanyl (Sublimaze)FDA LinkGeneric 09/01/2009 - "Fentanyl was less effective in subjects with the G allele of the OPRM1 A118G SNP than those with the A allele, and subjects with the G allele required more fentanyl for adequate postoperative pain control than those with the A allele. " 02/17/1989 - "A double-blind, placebo-controlled, randomized design was used to evaluate the safety and efficacy of transdermal fentanyl citrate for postoperative pain management in 42 healthy adult patients undergoing major shoulder surgery. " 01/01/2005 - "Clinical studies have shown that the fentanyl HCl PCTS is effective in the management of acute postoperative pain. " 03/01/1999 - "The addition of fentanyl may be effective for both intraoperative and postoperative pain relief. " 11/01/1992 - "DATA SYNTHESIS: Transdermal fentanyl was found to be effective in the control of chronic and postoperative pain. " Order ALL the reference details at left...
6.	Ketamine FDA LinkGeneric 05/01/1995 - "All 3 forms of ketamine consistently relieved postoperative pain, (S)-ketamine being 4 times more potent than (R)-ketamine. " 06/01/2008 - "The purpose of the present study was the clinical assessment of the efficacy of preincisional peritonsillar infiltration of two doses of ketamine on postoperative pain relief compared with peritonsillar saline in children undergoing adenotonsillectomy. " 03/01/2007 - "BACKGROUND: A few previous studies have suggested the efficacy of i.v. ketamine for postoperative pain relief in children after adenotonsillectomy, but none has investigated the efficacy of peritonsillar infiltration of ketamine in these children. " 05/01/2001 - "A prospective randomized controlled study of the efficacy of ketamine for postoperative pain relief in children after adenotonsillectomy." 01/01/1986 - "Thirty-four patients of ASA physical status I or II scheduled for gall bladder surgery were studied in a comparative prospective trial to evaluate the efficacy of epidural and intramuscular ketamine for postoperative pain relief. " Order ALL the reference details at left...
7.	Ibuprofen (Motrin)FDA LinkGeneric 01/01/2009 - "BACKGROUND: This review updates a 1999 Cochrane review showing that ibuprofen at various doses was effective in postoperative pain in single dose studies designed to demonstrate analgesic efficacy. " 09/01/2009 - "These findings suggest that ibuprofen 800 mg IV q6h was effective for postoperative pain management and was generally well tolerated. " 11/01/2002 - "CONCLUSION: There is no clinically meaningful difference in the efficacy of ibuprofen 400 mg between men and women experiencing moderate to severe postoperative pain and women were well represented." 07/13/1984 - "Controlled clinical trials have shown that ibuprofen (Motrin) is an effective and safe analgesic for patients with mild to moderate postoperative pain. " 11/01/1992 - "The purpose of the present study was to compare the efficacy of medicating with ibuprofen immediately presurgically to medicating immediately postsurgically on postoperative pain associated with periodontal surgery. " Order ALL the reference details at left...
8.	Analgesics (Analgesic Drugs)IBA 11/01/1999 - "INTERVENTIONS: An APS, nurse-based, anesthesiologist-supervised model was devised, based on the concept that postoperative pain relief can be greatly improved by providing in-service training for surgical nursing staff and optimal use of systemic analgesics. " 07/01/2009 - "In the test group there was a statistically significant reduction of postoperative pain in the 7 days after the extraction, and the patients had a consistent minor consumption of analgesics. " 09/01/1997 - "Moreover, the need for additional postoperative analgesics was significantly greater in groups 2 and 3. CONCLUSIONS: Oral KT is safe, convenient, and as effective as topical FS, and has the added advantage of reducing postoperative pain." 10/01/1992 - "The second day postoperative pain score in Group 1 was significantly greater than the first day score in the same group, and significantly greater than the severity score in Group 2. Only 36% of patients receiving two doses of EM required supplemental analgesics beyond 48 h compared to 76% of those receiving one dose (P < 0.01). " 02/01/2003 - "STUDY BACKGROUND: Nonpharmacological methods are stated to be effective in alleviating children's postoperative pain when used as an adjuvant to analgesics. " Order ALL the reference details at left...
9.	Diclofenac (SR 38)FDA LinkGeneric 01/01/1987 - "Efficacy of diclofenac in a single prophylactic dose in postoperative pain." 07/01/2004 - "PURPOSE: The purpose of this single-blind, placebo-controlled, 3-arm parallel, randomized study was to compare the analgesic efficacy and tolerability of a single dose of 100 mg diclofenac potassium (Cataflam; Novartis, Stein, Switzerland), 100 mg diclofenac sodium softgel, and placebo in patients experiencing moderate to severe postoperative pain after third molar extraction. " 01/01/2004 - "SELECTION CRITERIA: Randomised, double-blind, placebo-controlled clinical trials of single dose, oral diclofenac sodium or diclofenac potassium for acute postoperative pain in adults. " 12/01/1991 - "A randomised, controlled study was undertaken to assess the postoperative pain and side effects experienced by patients undergoing day case diagnostic laparoscopy and laparoscopic sterilisation, and to evaluate the effectiveness in these patients of peroperative diclofenac. " 08/01/1985 - "The study indicates that visual analogue scales may also be useful in assessment of swelling and that Voltaren in a fixed dosage offers a promising alternative against postoperative pain and swelling." Order ALL the reference details at left...
10.	Opioid Analgesics (Opioids)IBA 02/01/1988 - "Introduction: Several investigations have shown that constant rate infusions of opioids are highly effective in the provision of postoperative pain relief. " 12/01/2005 - "In addition, continuous peripheral nerve blocks showed effective and safe postoperative pain control, allowing for lower opioids consumption, improved and earlier rehabilitation, and high patient satisfaction. " 08/01/1988 - "Thus improved postoperative pain relief per se by PCA with systemic opioids had no major influence on the catabolic response to abdominal surgery." 01/01/2002 - "Clinical studies show that COX-2-selective inhibitors are effective for the treatment of preoperative and postoperative pain and reduce postsurgical requirements for opioids. " 07/01/2006 - "In this prospective, double-blind, randomized, placebo-controlled study we compared the efficacy of three IV non-opioid analgesics for postoperative pain relief after lumbar microdiscectomy. " Order ALL the reference details at left...

Therapies and Procedures

1.	Analgesia 11/01/2006 - "As a whole, assessment of analgesia within 24 hours showed excellent and good results reported by patients in 85% of cases; and in 71% of the patients the intensity of postoperative pain was less than they had expected before surgery. " 09/01/1984 - "The improved ventilation efficiency and the excellent immediate postoperative pain relief achieved by caudal analgesia justifies its frequent use for these operative surgical procedures." 09/01/2001 - "Clinically, there was a statistically significant (P<0.05) improvement in postoperative pain scores and use of opiate analgesia and an improvement (P>0.05) in respiratory function tests for patients in the cryoanalgesia group. " 10/01/1997 - "Postoperative pain did not surpass 3 on the VAS at rest or 4.5 while moving, although group F patients' need for complementary analgesia was significantly greater (p < 0.05). " 01/23/1995 - "However, late postoperative pain was significant and should be improved with multi-modal analgesia." Order ALL the reference details at left...
2.	Epidural Analgesia 03/01/1992 - "Although most studies suggest that epidural analgesia is superior for postoperative pain relief, few clearly demonstrate an improvement in pulmonary function attributable to epidural analgesia. " 04/01/1998 - "Thoracic epidural analgesia is effective for alleviating postoperative pain from corrective thoracic surgery in children. " 10/01/2003 - "The aim of the current study was to compare the efficacy of continuous thoracic epidural analgesia (EDA) to continuous intercostal (IC) block for postoperative pain and pulmonary function in a prospective, randomized, double-blinded clinical trial. " 03/01/2007 - "BACKGROUND: There is little published evidence of the analgesic efficacy of patient-controlled epidural analgesia (PCEA) for postoperative pain relief. " 10/01/2004 - "We aimed to assess the efficacy of multimodal epidural analgesia in decreasing postoperative pain after microdiscectomy. " Order ALL the reference details at left...
3.	Patient-Controlled Analgesia (Analgesia, Patient Controlled) 03/01/2008 - "Postoperative pain management has dramatically improved with the advent of patient-controlled analgesia (PCA) delivery. " 09/01/1997 - "BACKGROUND: Intravenous patient-controlled analgesia (PCA-i.v.) has has markedly improved postoperative pain-relief. " 06/01/1989 - "The purpose of this study was to determine if patient-controlled analgesia (PCA) is an effective method of postoperative pain relief for children. " 07/01/2009 - "BACKGROUND AND OBJECTIVES: Intravenous or epidural patient-controlled analgesia (PCA) is a safe and effective technique in the treatment of postoperative pain. " 09/15/2000 - "SUMMARY OF BACKGROUND DATA: Patient-controlled analgesia and epidural infusion are both safe and effective in controlling postoperative pain after PSIF. " Order ALL the reference details at left...
4.	Thoracotomy 08/01/2001 - "Recently, it has been shown that the video-assisted approach compared to the standard anterolateral thoracotomy results in a significant reduction of the early postoperative pain. " 03/01/1999 - "Thoracoscopic surgery is superior to thoracotomy in terms of less invasion and postoperative pain. " 03/01/1991 - "Continuous extrapleural intercostal nerve block has been shown in a randomized, controlled study to be effective in reducing postoperative pain after thoracotomy and in restoring pulmonary mechanics. " 08/01/2009 - "Continuous incisional infusion of local anesthetic through an extrapleural catheter to achieve an intercostal nerve block is a safe and effective adjunct to control postoperative pain after thoracotomy. " 04/01/1995 - "In a landmark study that compared video-assisted thoracoscopic surgery for peripheral lung lesions with thoracotomy, video-assisted thoracoscopic surgery reduced postoperative pain, improved early shoulder girdle function, and shortened hospital stay. " Order ALL the reference details at left...
5.	Laparoscopic Cholecystectomy 02/01/2007 - "BACKGROUND AND OBJECTIVE: Non-steroidal anti-inflammatory drugs are considered as an effective treatment of postoperative pain after laparoscopic cholecystectomy. " 09/01/2008 - "Randomized studies to compare single port laparoscopic cholecystectomy with traditional laparoscopic cholecystectomy, with specific regard to postoperative pain scores, would be helpful in determining how much additional benefit, if any, there is to the patient." 02/15/2001 - "Small-scale studies have suggested a large inter-individual variation in early postoperative pain after laparoscopic cholecystectomy, emphasizing the need for improved analgesic treatment and valid predictors. " 08/01/2009 - "Further studies are needed to determine its advantages in reference to postoperative pain and complication rate in juxtaposition with the current standard laparoscopic cholecystectomy." 09/01/2007 - "This study aimed to evaluate the effectiveness of an intraoperative intercostals neural blockade for the control of postoperative pain after laparoscopic cholecystectomy. " Order ALL the reference details at left...

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