Abstract | OBJECTIVE: DESIGN: A cross-sectional study was performed in 105 328 Korean adults who attended a health check-up programme. CAC score was assessed using CT, daily alcohol intake was recorded as grams/day and liver fat by ultrasound. Logistic regression model was used to calculate ORs with 95% CIs for prevalent CAC. RESULTS: Both NAFLD and AFLD were positively associated with CAC score. After adjusting for potential confounders, multivariable-adjusted OR (95% CIs) for CAC >0 comparing NAFLD and AFLD to the reference (absence of both excessive alcohol use and fatty liver disease) were 1.10 (95% CI 1.05 to 1.16) and 1.20 (95% CI 1.11 to 1.30), respectively. In post hoc analysis, OR (95% CI) for detectable CAC comparing AFLD to NAFLD was 1.09 (95% CI 1.01 to 1.17). Associations of NAFLD and AFLD with CAC scores were similar in both non-obese and obese individuals without significant interaction by obesity (p for interaction=0.088). After adjusting for homeostasis model assessment of insulin resistance and high-sensitivity C reactive protein, the associations between fatty liver disease and CAC scores remained statistically significant. CONCLUSION: In this large sample of young and middle-aged individuals, early liver disease due to NAFLD and AFLD were both significantly associated with the presence of coronary artery calcification.
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Authors | Yoosoo Chang, Seungho Ryu, Ki-Chul Sung, Yong Kyun Cho, Eunju Sung, Han-Na Kim, Hyun-Suk Jung, Kyung Eun Yun, Jiin Ahn, Hocheol Shin, Sarah Helen Wild, Christopher D Byrne |
Journal | Gut
(Gut)
Vol. 68
Issue 9
Pg. 1667-1675
(09 2019)
ISSN: 1468-3288 [Electronic] England |
PMID | 30472683
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ. |
Topics |
- Adolescent
- Adult
- Aged
- Calcinosis
(diagnostic imaging, epidemiology, etiology)
- Computed Tomography Angiography
- Coronary Angiography
(methods)
- Coronary Artery Disease
(diagnostic imaging, epidemiology, etiology)
- Cross-Sectional Studies
- Evidence-Based Medicine
(methods)
- Fatty Liver, Alcoholic
(complications, diagnostic imaging, epidemiology)
- Female
- Health Surveys
- Humans
- Male
- Middle Aged
- Non-alcoholic Fatty Liver Disease
(complications, diagnostic imaging, epidemiology)
- Republic of Korea
(epidemiology)
- Severity of Illness Index
- Ultrasonography
- Young Adult
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