A case of giant panda ovarian cancer diagnosis and histopathology.

Abstract

BACKGROUND:

Ovarian cancer is diagnosed clinically by detecting ovarian cancer-related factors and markers. Here, we report a case of giant panda ovarian tumor metastasis with a combination of clinical and histopathological diagnosis.

CASE PRESENTATION:

Histopathological studies revealed severe lesions and tumor cells in the ovaries, lungs, spleen, kidneys and perianal tissue. Immunohistochemistry staining showed that the ovarian cancer markers B7-H4, CA125, and HE4 were highly expressed in the lungs, kidneys, spleen, ovaries and perianal tissue. Tumor marker tests detected significantly high levels of AFP in serum.

CONCLUSION:

Clinical biomarkers combined with histopathology can provide a more accurate diagnosis of ovarian cancer metastasis and identification of ovarian cancer types than either method alone. The giant panda's death may be due to granulosa cell tumor and theca cell tumor metastasis causing multiple organ dysfunction or even failure.

• Authors: Qi Gao, Chengdong Wang, Desheng Li, Hemin Zhang, Linhua Deng, Caiwu Li, Zhengli Chen
• Journal: BMC veterinary research (BMC Vet Res) Vol. 14 Issue 1 Pg. 311 (Oct 12 2018) ISSN: 1746-6148 [Electronic] England
• PMID: 30314476 (Publication Type: Case Reports, Journal Article)

Chemical References

• Biomarkers, Tumor

Topics

• Animals
• Biomarkers, Tumor (analysis)
• Female
• Immunohistochemistry
• Neoplasm Metastasis
• Ovarian Neoplasms (diagnosis, pathology)
• Ursidae