Granulosa Cell Tumor

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314 relevant articles (18 outcomes, 36 trials/studies) found for this Disease

Description: A neoplasm composed entirely of GRANULOSA CELLS, occurring mostly in the OVARY. In the adult form, it may contain some THECA CELLS. This tumor often produces ESTRADIOL and INHIBIN. The excess estrogen exposure can lead to other malignancies in women and PRECOCIOUS PUBERTY in girls. In rare cases, granulosa cell tumors have been identified in the TESTES.

Also Known As:

Cancer of Granulosa Cells; Granulosa Cell Cancer; Cancer, Granulosa Cell; Cancers, Granulosa Cell; Cell Cancer, Granulosa; Cell Cancers, Granulosa; Cells Cancer, Granulosa; Cells Cancers, Granulosa; Granulosa Cell Cancers; Granulosa Cell Tumors; Granulosa Cells Cancer; Granulosa Cells Cancers; Tumor, Granulosa Cell; Tumors, Granulosa Cell

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Germ Cell and Embryonal Neoplasms (Germ Cell Tumor)
3.	Carcinoma (Carcinomatosis)
4.	Dysgerminoma
5.	Neoplasm Metastasis (Metastasis)

Experts

1.	Rey, R: 3 articles (09/2001 - 02/2000)
2.	Cramer, Andreas: 2 articles (07/2008 - 01/2008)
3.	Schmidt, Melanie: 2 articles (07/2008 - 01/2008)
4.	Pautier, P: 2 articles (05/2008 - 02/2000)
5.	Lhommé, C: 2 articles (05/2008 - 02/2000)
6.	Boerboom, Derek: 2 articles (02/2006 - 10/2005)
7.	Richards, Joanne S: 2 articles (02/2006 - 10/2005)
8.	Picard, J Y: 2 articles (09/2001 - 02/2000)
9.	Long, W Q: 2 articles (09/2001 - 02/2000)
10.	Roche, P C: 2 articles (11/2000 - 05/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Granulosa Cell Tumor:

1.	Inhibins (Inhibin)IBA 11/01/1994 - "In 13 subjects who were clinically disease free with a previous diagnosis of granulosa cell tumor, serum inhibin concentrations remained within the normal range for reproductive status. " 05/01/2004 - "Inhibin stain may be helpful in identifying granulosa cell tumors in cell block specimens." 01/01/1997 - "Serum inhibin level evaluation should be incorporated into large-group trials of therapy for granulosa cell tumors." 11/01/1994 - "The aim of this study was to determine if elevations in serum inhibin predated clinical recurrence in patients with a diagnosis of granulosa cell tumor. " 10/15/2009 - "Targeted disruption of the inhibin alpha gene (Inha(-)(/)(-)) in mice results in an ovarian phenotype of granulosa cell tumors that renders the animals infertile. " Order ALL the reference details at left...
2.	HormonesIBA 03/01/1996 - "CONCLUSION: Serum antimüllerian hormone is a sensitive, specific, reliable marker of adult-type granulosa cell tumors and is useful to evaluate the efficacy of treatment and to detect recurrences early." 06/01/2000 - "[Study on the anti-müllerian hormone served as a marker for granulosa cell tumor of ovary]" 11/01/2009 - "Many of these cells express anti-Müllerian hormone, and, histologically, the clusters resemble granulosa cell tumors in humans. " 10/01/2008 - "Anti-Müllerian hormone (AMH), also known as Müllerian inhibiting substance (MIS), is expressed by granulosa cells in females of many mammalian species, and circulating AMH concentrations have been used to monitor granulosa-cell tumors (GCT) in women. " 10/01/2008 - "Expression of anti-Müllerian hormone (AMH) in equine granulosa-cell tumors and in normal equine ovaries." Order ALL the reference details at left...
3.	Cisplatin (Platino)FDA LinkGeneric 01/01/1993 - "Cisplatin-based cytotoxic regimens may be of benefit in the treatment of recurrent or high risk granulosa-cell tumors." 01/01/1993 - "Cisplatin-based chemotherapy in recurrent or high risk ovarian granulosa-cell tumor patients." 03/01/2008 - "OBJECTIVES: The goal of the present study was to determine the efficacy of combinatorial treatment using cisplatin and tumor necrosis factor-related apoptosis including ligand (TRAIL) to promote apoptosis in granulosa cell tumor (GCT) lines, in vitro. " 12/01/1982 - "Combination chemotherapy of ovarian granulosa cell tumor with cis-platinum and doxorubicin." 02/01/1999 - "Bleomycin, etoposide, and cisplatin combination therapy of ovarian granulosa cell tumors and other stromal malignancies: A Gynecologic Oncology Group study." Order ALL the reference details at left...
4.	ParaffinIBA 11/01/2000 - "SPECIMEN(S): Eight granulosa cell tumors collected from paraffin-embedded tissue, eight Leydig cell tumors, and three thecomas collected from fresh-frozen or paraffin-embedded tissue. " 07/01/1992 - "Paraffin-embedded tissue from 38 patients with early- and advanced-stage juvenile granulosa cell tumor (JGCT) of the ovary was analyzed by flow cytometry to investigate whether the DNA content is related to the histologic features, stage, or clinical outcome. " 03/01/1990 - "The nuclear DNA content and S-phase fraction of 23 ovarian granulosa cell tumors were measured from paraffin-embedded tissue with flow cytometry. " 01/01/2007 - "STUDY DESIGN: Formalin-fixed paraffin-embedded archival tissue blocks of 20 unselected nonepithelial ovarian malignancies (12 granulosa cell tumors and 8 germ cell tumors) diagnosed between 1993 and 2005 were immunohistochemically stained for Her-2/neu. " 02/01/1990 - "The nuclear DNA content of 50 ovarian tumors initially diagnosed as granulosa cell tumors was measured by flow cytometry using paraffin-embedded archival material. " Order ALL the reference details at left...
5.	Aromatase (CYP19)IBA 07/01/2009 - "We describe 4 patients in whom recurrent ovarian granulosa cell tumors were treated with an aromatase inhibitor, with promising results." 02/01/1994 - "In the present study, we investigated the regulatory elements directing P450arom gene transcription in samples of SCTAT from three prepubertal boys and a girl with P-JS and an ovarian granulosa cell tumor from an adult woman, as well as in healthy fetal and adult testicular and ovarian tissues. " 12/01/1993 - "In the present study, we investigated the regulatory elements directing P450arom gene transcription in samples of SCTAT from three prepubertal boys and a girl with P-JS and an ovarian granulosa cell tumor from an adult woman, as well as in healthy fetal and adult testicular and ovarian tissues. " 08/01/2007 - "Granulosa cell tumors of the ovary are rare, hormonally sensitive tumors, with reported responses to a variety of hormonal manipulations, including aromatase inhibition. " 10/01/1993 - "Aromatase activity was detected in 35 tumors (81%), PR in 21 tumors (49%) and ER in 13 tumors (30%) out of 43 ovarian tumors (27 benign, 14 malignant and 2 granulosa cell tumors). " Order ALL the reference details at left...
6.	Formaldehyde (Formol)IBA 01/01/2007 - "STUDY DESIGN: Formalin-fixed paraffin-embedded archival tissue blocks of 20 unselected nonepithelial ovarian malignancies (12 granulosa cell tumors and 8 germ cell tumors) diagnosed between 1993 and 2005 were immunohistochemically stained for Her-2/neu. " 11/01/2005 - "METHODS: Immunohistochemical study for OCT4 was performed on formalin-fixed, paraffin-embedded tissues of 63 cases of germ cell tumors, including seminoma (21), dysgerminoma (7), germinoma (8), embryonal carcinoma (8), yolk sac tumor (6), mature teratoma (10) and immature teratoma (3), as well as 25 cases of non-germ cell tumors, including granulosa cell tumor (8), clear cell adenocarcinoma (4), Leydig's cell tumor (5), diffuse large B-cell lymphoma (4) and malignant melanoma (4). " 12/01/1997 - "To determine the efficacy of this marker for distinguishing granulosa cell tumors, 134 primary and metastatic lesions of the ovary were evaluated for expression of the alpha-subunit of inhibin in routinely processed formalin-fixed, paraffin-embedded tissue. " 01/01/1999 - "BACKGROUND AND METHODS: Because the use of immunohistochemistry in the diagnosis of granulosa cell tumor (GCT) has not been fully explored, routinely processed (formalin-fixed, paraffin-embedded) tissue from 11 GCT, adult type, was investigated immunohistochemically (ABC method) with a broad spectrum of antibodies against various markers, including p53 and Ki-67. " 07/01/2007 - "Formalin-fixed, paraffin-embedded tissue sections from 4 normal ovaries, 8 granulosa cell tumors, and 6 epithelial ovarian tumors (2 adenomas and 4 adenocarcinomas) sections were obtained and stained with hematoxylin and eosin and immunohistochemically for cytokeratin AE1/AE3, cytokeratin 7, vimentin, and inhibin-alpha. " Order ALL the reference details at left...
7.	Keratins (Keratin)IBA 06/01/2003 - "We conclude that because cytokeratin is frequently expressed by SCSTs, in particular by granulosa cell tumors, SLCTs, and SCTATs, the inclusion of EMA in a panel may help to exclude epithelial neoplasms. " 07/01/2007 - "Cytokeratin AE1/AE3 was expressed by all epithelial-derived tumors and 6 of 8 granulosa cell tumors. " 01/01/1992 - "We think that cytokeratin immunohistochemistry is of value in differentiating between granulosa cell tumors and ovarian carcinomas." 01/01/1992 - "The other keratins we investigated showed higher expression rates in granulosa cell tumors and/or lower expression rates in ovarian carcinomas. " 09/01/1995 - "The present study describes three ovarian neoplasms in which the immunohistochemical and ultrastructural findings support a stromal origin for the cells, and a fourth tumor that simulated the other three closely on light microscopic examination but had several features supporting a sex-cord rather than stromal origin: immunohistochemical staining for keratin and alpha smooth muscle actin, and globular keratin staining, similar to that seen in granulosa cell tumors; and numerous prominent junctions including desmosomes on electron microscopy. " Order ALL the reference details at left...
8.	inhibin AIBA 05/01/2007 - "METHODS: In 30 consecutive patients with a stage I-III granulosa cell tumor, inhibin A and B concentrations were measured in pre- and post-treatment serum samples. " 05/01/2007 - "OBJECTIVES: In patients with a granulosa cell tumor of the ovary, the value of serum inhibin A and B concentrations for the assessment of disease status was investigated. " 05/01/2007 - "Granulosa cell tumors of the ovary: the clinical value of serum inhibin A and B levels in a large single center cohort." 03/01/1998 - "Only one of eight patients with a progressive granulosa cell tumor had a high value of serum inhibin A. " 03/01/1999 - "BACKGROUND AND OBJECTIVE: Previous studies have shown that serum inhibin as measured by alpha subunit-directed radioimmunoassay (RIA) and inhibin A ELISA was elevated in postmenopausal women with mucinous and granulosa cell cancers, with the RIA showing a more frequent elevation than the inhibin A ELISA. " Order ALL the reference details at left...
9.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 03/01/2008 - "OBJECTIVES: The goal of the present study was to determine the efficacy of combinatorial treatment using cisplatin and tumor necrosis factor-related apoptosis including ligand (TRAIL) to promote apoptosis in granulosa cell tumor (GCT) lines, in vitro. " Order ALL the reference details at left...
10.	Estradiol (Estrace)FDA LinkGeneric 08/01/1990 - "Estradiol treatment before but not after preneoplastic lesions appeared inhibited granulosa cell tumor formation. " 03/01/1983 - "Ovarian granulosa cell tumors--immunohistochemical localization of estradiol and ultrastructure, with functional correlations." 06/01/1986 - "A literature review reveals two previous cases in which this combination has been reported as being effective in advanced granulosa cell tumor, but this is the first report of the use of serum estradiol as a tumor marker." 09/01/2005 - "PATIENT(S): Three patients: a 31-year-old woman with primary infertility, recurrent adnexal masses, and highly elevated estradiol level; a 30-year-old woman with recurrent multicystic ovaries following multiple cystectomies and transvaginal cyst aspirations, and elevated estradiol level; a 43-year-old woman with bilateral complex cystic adnexal masses and an elevated estradiol level, who underwent a total abdominal hysterectomy and bilateral salpingo-oophorectomy for a suspected granulosa cell tumor. " 01/01/2008 - "The granulosa-cell tumor is a hormone active one, originating from granulosa cells which produce estradiol. " Order ALL the reference details at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 09/01/2009 - "OBJECTIVE: Ovarian granulosa cell tumors tend to respond poorly to chemotherapy. " 08/01/2009 - "We report the case of an advanced granulosa cell tumor of the testis with a confirmed partial response to an angiogenesis inhibitor after initial resistance to cytotoxic chemotherapy." 07/01/2009 - "Recurring adult-type granulosa cell tumors of the ovary are usually treated by surgical resection followed by chemotherapy or radiation. " 12/01/2005 - "BACKGROUND: Ovarian granulosa cell tumors (GCT) are usually treated by surgery and chemotherapy. " 07/01/2002 - "CONCLUSION: CIIPHCP appears to offer a promising procedure in addition to surgical debulking and systemic chemotherapy for treatment of advanced or recurrent ovarian granulosa cell tumors. " Order ALL the reference details at left...
2.	Heterologous Transplantation (Xenotransplantation) 01/01/2005 - "The achievable, consistently high engraftment rate allows use of such xenografts as tools for studying a wide range of ovarian tumors, including granulosa cell tumors and benign, borderline, and malignant surface epithelial neoplasms. " 09/01/1984 - "One ovarian granulosa cell tumor and its xenograft (V7) were tested against several cytotoxic agents. " 11/01/2005 - "Hecate-betaCG was less effective in mice bearing ovarian epithelial cancer cell xenografts, but was highly effective in treating granulosa cell tumors in transgenic mice. " Order ALL the reference details at left...
3.	Aftercare (After-Treatment) 06/01/1999 - "OBJECTIVE: We report a case of metastatic ovarian granulosa cell tumor in the mediastinum with a 2-year disease-free interval after treatment with radiotherapy and review the literature regarding the use of radiotherapy in recurrent and metastatic granulosa cell tumor. " 01/01/1980 - "Eight of the granulosa-cell tumor group gave birth to 12 children after treatment for the tumor. " 01/01/1992 - "[Metastasis surgery in granulosa cell tumor--determining indications and tumor after care]" Order ALL the reference details at left...
4.	Traction 07/15/1997 - "All of these factors improved exposure, decreased traction on the ovary, increased our ability to observe the vasculature, and decreased postoperative morbidity, aiding in the removal of granulosa cell tumors in mares." Order ALL the reference details at left...
5.	Ovariectomy (Oophorectomy) 01/01/1997 - "STUDY DESIGN: Serum samples were collected following bilateral oophorectomy (BSO) with or without other indicated surgery in 15 patients with granulosa cell tumors. " 03/01/2009 - "Six weeks later, a tumoral relapse occurred and completion of oophorectomy revealed a juvenile granulosa cell tumor (JGCT). " 10/01/2000 - "A 62-year-old woman undergoing left salpingo-oophorectomy for a granulosa cell tumor of the left ovary 15 years earlier presented with abnormal chest shadows. " 08/01/2000 - "Reported techniques using a ventral approach in the mare include bilateral ovariectomy and granulosa cell tumor removal. " 07/01/1999 - "Women who have undergone oophorectomy may have the potential to develop granulosa cell tumors." Order ALL the reference details at left...

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