Abstract | BACKGROUND: Aspergillus fumigatus is a major cause of allergic syndromes, aspergilloma and life-threatening invasive infections in immunocompromised hosts. To date, a wide range of mutations in A. fumigatushave been described conferring azole-resistance, which commonly involves modifications in the cyp51A-gene (substitutions at codons G54, G138, P216, F219, M220, G448 and specifically codon L98 in combination with a 34-bp tandem repeat in the promoter region of the gene), the target for azole antifungals. We investigated the prevalence of azole-resistance in clinical A. fumigatus isolates obtained from patients in Iran during 2010 to 2014. METHODS: RESULTS: Of 172 A. fumigatus isolates tested, six isolates (3.5%) had high MIC values of ITC (>16 mg/L) and VRC (≥4 mg/L). All six isolates showed a multi-resistant phenotype with high MICs of ITC and VRC. CONCLUSION: We determined in-vitro susceptibility a profile of 172 clinically isolates of A. fumigatus against triazole in Iran. Azole-resistance is an emerging problem in A. fumigatus and international surveillance is warranted.
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Authors | Faezezeh Mohammadi, Seyed Jamal Hashemi, Seyed Mojtaba Seyedmousavi, Dorna Akbarzade |
Journal | Iranian journal of public health
(Iran J Public Health)
Vol. 47
Issue 7
Pg. 994-1000
(Jul 2018)
ISSN: 2251-6085 [Print] Iran |
PMID | 30181998
(Publication Type: Journal Article)
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