Effects of an ethanol extract from Lactobacillus paracasei subsp. paracasei NTU 101 fermented skimmed milk on lipopolysaccharide-induced periodontal inflammation in rats.

Abstract	The increased incidence of periodontal disease in recent years has garnered considerable attention. Numerous studies have confirmed that probiotics, such as lactic acid bacteria, can ameliorate periodontal inflammation. The current study aimed to assess the effect of an ethanol extract of Lactobacillus paracasei subsp. paracasei NTU 101-fermented skimmed milk (NTU101FM) on lipopolysaccharide (LPS)-induced periodontal inflammation in rats. NTU101FM ethanol extract significantly ameliorated the weight loss caused by periodontal inflammation. NTU101FM ethanol extract treatment also reduced the oral microbial levels and decreased the levels of alveolar bone loss. Finally, NTU101FM ethanol extract was found to ameliorate periodontal inflammation by decreasing the levels of pro-inflammatory cytokines and reducing oxidative stresses induced by LPS. Overall, our findings demonstrate that NTU101FM ethanol extract could be developed as a functional food that could ameliorate periodontal inflammation.
Authors	Te-Hua Liu , Tsung-Yu Tsai , Tzu-Ming Pan
Journal	Food & function (Food Funct) Vol. 9 Issue 9 Pg. 4916-4925 (Sep 19 2018) ISSN: 2042-650X [Electronic] England
PMID	30178812 (Publication Type: Comparative Study, Journal Article)
Chemical References	Anti-Infective Agents Anti-Inflammatory Agents, Non-Steroidal Antioxidants Biological Products Bone Density Conservation Agents Lipopolysaccharides Solvents lipopolysaccharide, E coli O55-B5 Ethanol
Topics	Alveolar Bone Loss (etiology, prevention & control) Animals Anti-Infective Agents (administration & dosage, therapeutic use) Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, therapeutic use) Antioxidants (administration & dosage, therapeutic use) Biological Products (administration & dosage, therapeutic use) Bone Density Conservation Agents (administration & dosage, therapeutic use) Cultured Milk Products (analysis, microbiology) Diet, Fat-Restricted Dietary Supplements Ethanol (chemistry) Fermentation Lacticaseibacillus paracasei (chemistry, growth & development, metabolism) Lipopolysaccharides (toxicity) Male Mouth Mucosa (immunology, metabolism, microbiology) Oxidative Stress Periodontitis (chemically induced, immunology, physiopathology, prevention & control) Periodontium (immunology, metabolism, microbiology) Random Allocation Rats, Sprague-Dawley Solvents (chemistry)

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