Abstract | BACKGROUND: OBJECTIVE: METHODS: A population-based cohort study of 261,638 statin-free individuals (aged 40-79 years at their first serum cholesterol test, 42.7% men), with repeated measures of total, low, and high-density lipoprotein cholesterol was performed from 1999 to 2012. Individuals were followed from their first cholesterol test until PD incidence, death, or end of study. The PD incidence was assessed using a validated antiparkinsonian-drug tracing approach. Cox models stratified by sex and age with time-dependent cholesterol variables were applied to estimate PD hazard ratios. RESULTS: CONCLUSIONS:
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Authors | Violetta Rozani, Tanya Gurevich, Nir Giladi, Baruch El-Ad, Judith Tsamir, Beatriz Hemo, Chava Peretz |
Journal | Movement disorders : official journal of the Movement Disorder Society
(Mov Disord)
Vol. 33
Issue 8
Pg. 1298-1305
(08 2018)
ISSN: 1531-8257 [Electronic] United States |
PMID | 30145829
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2018 International Parkinson and Movement Disorder Society. |
Chemical References |
- Antiparkinson Agents
- Cholesterol
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Topics |
- Adult
- Age Factors
- Aged
- Algorithms
- Antiparkinson Agents
(therapeutic use)
- Cholesterol
(blood)
- Cohort Studies
- Community Health Planning
- Female
- Humans
- Incidence
- Male
- Middle Aged
- Parkinson Disease
(blood, drug therapy, epidemiology)
- Proportional Hazards Models
- Risk Factors
- Sex Factors
- Time Factors
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