Abstract |
This study investigated the effect of 7-chloro-4-(phenylselanyl) quinoline (4-PSQ) at a dose of 1 mg/kg in memory impairment and anxiety in an Alzheimer's disease (AD) model induced by amyloid β- peptide (Aβ) (fragment 25-35) in mice. The involvement of acetylcholinesterase (AChE) activity and lipid peroxidation in hippocampus and cerebral cortex was evaluated. Male Swiss mice were pretreated with 4-PSQ (1 mg/kg, intragastrically (i.g.), daily) for fourteen days. Thirty minutes after the first treatment with 4-PSQ, the animals received a single injection of Aβ (3 nmol/3 μl/per site, intracerebroventricular (i.c.v.)). Mice were submitted to the behavioral tasks (open-field, elevated plus maze, Barnes maze, object recognition and location, and step-down inhibitory avoidance tests) from the fifth day onwards. On the fifteenth day, blood was removed for analysis of biochemical markers ( glucose, triglycerides, urea, aspartate (AST) and alanine (ALT) aminotrasferases), and cerebral cortex and hippocampus for determination of AChE activity and thiobarbituric acid reactive species ( TBARS) levels. Aβ caused memory impairment, anxiogenic behavior, increased AChE activity in the cerebral structures and TBARS levels in the cerebral cortex. 4-PSQ was effective to protect against behavioral changes, AChE activity and TBARS levels. In conclusion, 4-PSQ protected against learning and memory impairment and anxiety in a mouse model of AD induced by Aβ, and anticholinesterase and antioxidant actions are involved in the pharmacological effect of the compound.
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Authors | Mikaela P Pinz, Angélica S Dos Reis, Ane G Vogt, Roberta Krüger, Diego Alves, Cristiano R Jesse, Silvane S Roman, Mauro P Soares, Ethel A Wilhelm, Cristiane Luchese |
Journal | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
(Biomed Pharmacother)
Vol. 105
Pg. 1006-1014
(Sep 2018)
ISSN: 1950-6007 [Electronic] France |
PMID | 30021335
(Publication Type: Journal Article)
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Copyright | Copyright © 2018 Elsevier Masson SAS. All rights reserved. |
Chemical References |
- 7-chloro-4-phenylsulfonyl quinoline
- Amyloid beta-Peptides
- Peptide Fragments
- Quinolines
- amyloid beta-protein (25-35)
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Topics |
- Alzheimer Disease
(chemically induced, drug therapy, metabolism)
- Amyloid beta-Peptides
(toxicity)
- Animals
- Anxiety
(chemically induced, metabolism, prevention & control)
- Cognitive Dysfunction
(chemically induced, metabolism, prevention & control)
- Disease Models, Animal
- Locomotion
(drug effects, physiology)
- Male
- Maze Learning
(drug effects, physiology)
- Mice
- Peptide Fragments
(toxicity)
- Quinolines
(pharmacology, therapeutic use)
- Random Allocation
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