Cholinesterase Inhibitors (Anticholinesterases)

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1187 relevant articles (134 outcomes, 146 trials/studies) found for this Bio-Agent

Description: Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.

Also Known As:

Anticholinesterases; Acetylcholinesterase Inhibitors; Anti-Cholinesterases; Anticholinesterase Drugs; Cholinesterase Inhibitors, Irreversible; Cholinesterase Inhibitors, Reversible; Agents, Anticholinesterase; Anti Cholinesterases; Drugs, Anticholinesterase; Inhibitors, Acetylcholinesterase; Inhibitors, Cholinesterase; Inhibitors, Irreversible Cholinesterase; Inhibitors, Reversible Cholinesterase; Irreversible Cholinesterase Inhibitors; Reversible Cholinesterase Inhibitors; Anticholinesterase Agents

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses

Pharmacologic Actions: 49

Molecular Mechanisms of Pharmacological Action: 5

Neurotransmitter Agents: 5720

Cholinergic Agents: 324

Cholinesterase Inhibitors: 1187

Enzyme Inhibitors: 603

Cholinesterase Inhibitors: 1187

Physiological Effects of Drugs: 1

Neurotransmitter Agents: 5720

Cholinergic Agents: 324

Cholinesterase Inhibitors: 1187

Experts

1.	Padovani, Alessandro: 5 articles (06/2007 - 06/2003)
2.	Burns, A: 4 articles (01/2008 - 11/2002)
3.	Gauthier, Serge: 4 articles (06/2006 - 01/2003)
4.	Borroni, Barbara: 4 articles (06/2005 - 06/2003)
5.	Di Luca, Monica: 4 articles (06/2005 - 06/2003)
6.	Giacobini, E: 4 articles (01/2002 - 01/2000)
7.	Connelly, Peter J: 3 articles (02/2008 - 02/2004)
8.	Schneider, Lon S: 3 articles (09/2007 - 05/2003)
9.	Finucane, Thomas E: 3 articles (03/2006 - 10/2002)
10.	Alisky, Joseph Martin: 3 articles (01/2006 - 12/2003)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 04/01/2003 - "The most important therapeutic effect of cholinesterase inhibitors (ChEI) on approximately 50% of Alzheimer's disease (AD) patients is to stabilize cognitive function at a steady level during a 1-year period of treatment as compared to placebo. " 01/01/2002 - "Cholinesterase inhibitors have produced the best evidence of clinical efficacy for treating patients with Alzheimer's disease (AD). " 08/01/2006 - "PURPOSE: Cholinesterase Inhibitors (ChEIs) have proven efficacy in outpatients with mild to moderate Alzheimer's Disease (AD). " 02/01/2001 - "Despite the proven efficacy of acetylcholinesterase inhibitors in Alzheimer's disease, there is a need for new and more effective treatments. " 02/01/1997 - "Although some promising results have been achieved by acetylcholinesterase inhibitors, an effective therapeutic intervention in Alzheimer's disease still remains an important goal. " Order ALL the reference details at left...
2.	Dementia (Dementias) 01/01/2004 - "Observations on the neurochemistry of dementia with Lewy bodies (DLB) have suggested that cholinesterase inhibitors (ChEIs) might be beneficial in treating some clinical symptoms of DLB. " 04/01/2005 - "Recent evidence from small double-blind and open-label trials suggests that cholinesterase inhibitors may be effective in the treatment of dementia associated with PD." 08/01/2004 - "Several small studies with three different cholinesterase inhibitors suggest that these drugs can be effective in the treatment of PD dementia. " 04/01/2003 - "Recent evidence from small studies suggests that cholinesterase inhibitors may be effective in the treatment of dementia associated with PD." 06/01/2009 - "CONCLUSIONS: This case confirms the idea that treatment with cholinesterase inhibitors can be effective in the behavioural and psychological symptoms of frontotemporal dementia." Order ALL the reference details at left...
3.	Myasthenia Gravis 02/01/2009 - "Acetylcholinesterase inhibitors are the first line treatment with the rapid onset of effect, for all types of myasthenia gravis (ocular, generalized myasthenia gravis, seronegative or seropositive patients). " 09/15/2008 - "In Myasthenia Gravis (MG), diagnosis and symptomatic therapy are based on cholinergic modulation by acetylcholinesterase inhibitors (AChEI). " 09/15/2008 - "Acetylcholinesterase inhibitors and cholinergic modulation in Myasthenia Gravis and neuroinflammation." 03/01/2008 - "The aim of this prospective study was to assess whether extra discharges (EDs), sometimes following the compound muscle action potential, could be used as a neurophysiological indicator of overdose of acetylcholinesterase inhibitors (AChEIs) in patients with myasthenia gravis (MG). " 03/01/2008 - "Electrophysiological signs and the prevalence of adverse effects of acetylcholinesterase inhibitors in patients with myasthenia gravis." Order ALL the reference details at left...
4.	Neurobehavioral Manifestations 01/01/2007 - "The effects of potential mediators and confounders (demographic factors, neuropsychiatric symptoms, cognitive severity and cholinesterase inhibitors) were also examined. " 06/01/2005 - "CONCLUSION: Cholinesterase inhibitors have a moderate effect against cognitive symptoms. " 01/01/1998 - "Clinical pharmacologic approaches toward improvement of cognitive symptoms are discussed, with an emphasis on cholinergic approaches, since they currently appear most promising and since several cholinesterase inhibitors may soon be available for prescribing. " 07/01/2007 - "Acetylcholinesterase inhibitors (AChEIs) are effective in the treatment of cognitive symptoms in Alzheimer's disease (AD). " 11/01/2002 - "Anticholinesterases are known to be effective against cognitive and non-cognitive symptoms of Alzheimer's disease (AD) but their effect on the personality changes in the disease is not known. " Order ALL the reference details at left...
5.	Poisoning 03/16/2004 - "In recent years a number of studies have drawn attention to the possible neuropsychological sequelae stemming from acute poisoning by certain substances, namely cholinesterase inhibitors. " 01/01/1997 - "The aim of this study was to evaluate a morphological and functional status of the CNS in acute cholinesterase inhibitors (ChI) poisonings using the brain computer tomography (CT) and complex psychiatric examination. " 12/01/2008 - "Those poisoned with acetylcholinesterase inhibitors stayed longer and most of them displayed pronounced clinical signs of poisoning (Poisoning Severity Score grades 2-4); 14 of the 18 deaths reported occurred with these products. " 11/01/2008 - "Poisoning with organophosphorus cholinesterase inhibitors (OPCs) poses a serious global threat. " 01/01/2006 - "Developing embryos are more vulnerable than adults to acute cholinergic intoxication by anticholinesterases, including organophosphorus pesticides. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	donepezil (Aricept)
2.	rivastigmine (Exelon)
3.	Galantamine (Galanthamine)
4.	Acetylcholine (Acetylcholine Chloride)
5.	Memantine (Namenda)
6.	Tacrine (Cognex)
7.	Trichlorfon (Metrifonate)
8.	Cholinergic Agonists
9.	Cholinergic Agents (Cholinergics)
10.	Neostigmine (Neostigmine Bromide)

Related Therapies and Procedures

1.	Thymectomy
2.	Activities of Daily Living (ADL)
3.	Plasmapheresis
4.	Plasma Exchange
5.	Aftercare (After-Treatment)

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