Expression of IncRNA UCA1 in ovarian cancer and its clinical significance.

Abstract

OBJECTIVES:

To explore the expression and clinical significance of IncRNA-UCA1 in ovarian cancer.

MATERIALS AND METHODS:

The ex- pression of IncRNA-UCA1 in 26 ovarian cancer tissue and 16 normal and benign ovarian tissue were detected using qRT-PCR method, and the correlation of expression level with clinicopathological features were analyzed.

RESULTS:

Higher lncRNA-UCA1 expression level were detected in ovarian cancer tissue than those in normal ovarian tissue (p < 0.05). There were significant correlations between higher expression of IncRNA-UCA1 with tumor staging (p = 0.000), histological grades (p = 0.000), peritoneal effusion (p = 0.001), and lymph node metastasis (p = 0.000), but not with age.

CONCLUSION:

IncRNA-UCA1 may play a vital role in the metastasis of ovarian cancer and it is expected to be a potential novel biomarker and therapeutic target of ovarian cancer.

• Authors: Y R Qiu, M Y Zhao, L Sun, B C Yang, K W Hei, X Du, Y M Li
• Journal: European journal of gynaecological oncology (Eur J Gynaecol Oncol) Vol. 38 Issue 2 Pg. 191-195 ( 2017) ISSN: 0392-2936 [Print] Singapore
• PMID: 29953778 (Publication Type: Journal Article)

Chemical References

• RNA, Long Noncoding
• UCA1 RNA, human

Topics

• Ascitic Fluid
• Cell Line, Tumor
• Female
• Humans
• Lymphatic Metastasis
• Middle Aged
• Neoplasm Grading
• Neoplasm Staging
• Ovarian Neoplasms (complications, genetics, pathology)
• Ovary (metabolism)
• RNA, Long Noncoding (genetics, metabolism)
• Retrospective Studies