Abstract | INTRODUCTION: The management of chronic, nonhealing wounds in patients with multiple comorbidities continues to be a challenge for health care practitioners. Chronic wounds typically do not progress through the normal phases of wound healing and generally remain stagnant during the inflammatory phase, resulting in an increase in proteolytic enzymes with degradation of the extracellular matrix. Bacterial biofilm has been documented to be one of the main factors delaying wound healing, resulting in the prolongation of the inflammatory phase. OBJECTIVE: In order to control biofilm formation, sequester proteolytic enzymes, and provide a biocompatible scaffold to support healing, the investigators utilize a purified collagen matrix containing polyhexamethylene biguanide ( PCMP) in a case series of 9 wounds on 8 patients with multiple comorbidities who did not respond to previous conventional or adjuvant therapy. MATERIALS AND METHODS: RESULTS: Patients received an average of 5.8 PCMP applications. Of the 6 wounds that healed, average time to closure from the first PCMP application was 10 weeks. The remaining 3 wounds demonstrated improved wound appearance with 100% granulation tissue and an average area reduction during PCMP treatment of 61.4%. CONCLUSIONS: This case series demonstrated that PCMP along with good wound care supported both wound closure and improvements in wound bed condition and area reduction on recalcitrant, nonhealing wounds of various etiologies.
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Authors | Dimitrios Lintzeris, Karen Vernon, Heather Percise, Andy Strickland, Kari Yarrow, Amber White, Mary Gurganus, Susan Sherrod, Kathleen Vergin, Laura Johnson |
Journal | Wounds : a compendium of clinical research and practice
(Wounds)
Vol. 30
Issue 3
Pg. 72-78
(Mar 2018)
ISSN: 1943-2704 [Electronic] United States |
PMID | 29584602
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Anti-Infective Agents, Local
- Biguanides
- Collagen Type I
- polihexanide
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Topics |
- Aged
- Anti-Infective Agents, Local
(therapeutic use)
- Biguanides
(therapeutic use)
- Calciphylaxis
(complications)
- Chronic Disease
- Collagen Type I
(therapeutic use)
- Diabetic Foot
(therapy)
- Female
- Humans
- Male
- Middle Aged
- Pressure Ulcer
(therapy)
- Skin Ulcer
(etiology, therapy)
- Surgical Wound Dehiscence
(therapy)
- Varicose Ulcer
(therapy)
- Wound Healing
(physiology)
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