Pressure Ulcer (Bedsore)

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1511 relevant articles (84 outcomes, 231 trials/studies) found for this Disease

Description: An ulceration caused by prolonged pressure on the SKIN and TISSUES when one stay in one position for a long period of time, such as lying in bed. The bony areas of the body are the most frequently affected sites which become ischemic (ISCHEMIA) under sustained and constant pressure.

Also Known As:

Bedsore; Bedsores; Decubitus Ulcers; Decubitus Ulcer; Bed Sores; Bed Sore; Pressure Sores; Pressure Ulcers; Sore, Bed; Sore, Pressure; Sores, Bed; Sores, Pressure; Ulcer, Decubitus; Ulcer, Pressure; Ulcers, Decubitus; Ulcers, Pressure; Pressure Sore

Relationship Network

Disease Context: Research Results

Skin and Connective Tissue Diseases

Skin Diseases: 6187

Skin Ulcer: 344

Pressure Ulcer: 1511

Related Diseases

1.	Wounds and Injuries (Trauma)
2.	Pressure Ulcer (Bedsore)
3.	Ulcer
4.	Leg Ulcer
5.	Burns

Experts

1.	Snoeckx, Luc H E H: 5 articles (11/2007 - 04/2005)
2.	Duimel-Peeters, Inge G P: 5 articles (11/2007 - 04/2005)
3.	Smout, Randall J: 5 articles (11/2005 - 11/2002)
4.	Horn, Susan D: 5 articles (11/2005 - 11/2002)
5.	Stechmiller, Joyce K: 4 articles (10/2008 - 11/2004)
6.	Halfens, Ruud J G: 4 articles (03/2008 - 04/2005)
7.	Berger, Martijn P F: 4 articles (04/2006 - 04/2005)
8.	Bergstrom, Nancy: 4 articles (11/2005 - 11/2002)
9.	Bender, Stacy A: 4 articles (10/2005 - 11/2002)
10.	Ferguson, Maree L: 4 articles (10/2005 - 11/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pressure Ulcer:

1.	Colloids (Colloid)IBA 05/01/2008 - "RELEVANCE TO CLINICAL PRACTICE: Based on the studies included in this review, hydrocolloids are frequently used in the treatment of grade 2 and 3 pressure ulcers and are more effective and less expensive than gauze dressings. " 05/01/2008 - "Randomised controlled trials on the treatment of pressure ulcers with hydrocolloids, as defined by the British National Formulary, were systematically included and analysed. " 03/01/1999 - "A new amorphous hydrocolloid for the treatment of pressure sores: a randomised controlled study." 12/01/1998 - "Pressure ulcers--randomised controlled trial comparing hydrocolloid and saline gauze dressings." 10/01/2008 - "Review: evidence of the effectiveness of hydrocolloids for healing pressure ulcers is limited." Order ALL the reference details at left...
2.	alginic acid (sodium alginate)IBA 08/01/1991 - "Severely debilitated patients with full-thickness pressure ulcers were treated for one week to three months with one of these alginate dressings (Kaltostat). " 08/01/1991 - "Evaluation of an alginate dressing for pressure ulcers." 05/01/1990 - "The use of a calcium alginate dressing in the management of decubitus ulcers in patients with spinal cord lesions." 02/01/2002 - "Sequential treatment with calcium alginate dressings and hydrocolloid dressings accelerates pressure ulcer healing in older subjects: a multicenter randomized trial of sequential versus nonsequential treatment with hydrocolloid dressings alone." 12/09/2004 - "This study investigates whether vacuum-assisted closure (VAC) therapy, alginate or hydrocolloid dressing are most effective in the treatment of pressure ulcers. " Order ALL the reference details at left...
3.	OxygenIBA 01/01/2006 - "RESULTS: The intraoperative improvement of cutaneous blood flow and oxygen tension in the systemically warmed group improved tissue viability and reduced the incidence of pressure sores. " 12/01/1983 - "Skin oxygen tension measurement allows immediate assessment of the efficacy of measures to prevent decubitus ulcers." 11/01/2000 - "In a prospective, controlled study the skin microcirculation and transcutaneous oxygen tension were evaluated in 28 elderly patients (85 +/- 0.8 years) with grade 2 and 3 pressure ulcer. " 11/01/1998 - "In this study, interface pressures, transcutaneous oxygen tension (TcPO2), and blood flow were compared with the classic pressure ulcer-prone areas in the supine and lateral position on six different high- and low-air-loss support surfaces. " 05/01/1993 - "With a view to developing a new method of preventing pressure ulcers, the objective of this study was to determine whether high voltage pulsed galvanic stimulation (HVPGS) could increase sacral transcutaneous oxygen tension (PtcO2) in SCI persons lying prone and supine. " Order ALL the reference details at left...
4.	HydrogelIBA 01/01/2005 - "The effectiveness of a hydrogel dressing compared with standard management of pressure ulcers." 09/01/1996 - "Hydrogel dressings should be considered as one component of an individualized plan of care for the development of pressure ulcers." 09/01/1996 - "In this article, the authors describe four case studies of clients with SCI who have pressure ulcers and discuss the implementation and outcome of a nursing management protocol based on the use of hydrogel dressings. " 09/01/1996 - "Nursing management of pressure ulcers using a hydrogel dressing protocol: four case studies." 07/01/1990 - "Biofilm hydrogel dressing: a clinical evaluation in the treatment of pressure sores." Order ALL the reference details at left...
5.	dextranomerIBA 06/13/1981 - "The treatment of decubitus ulcers with dextranomer." 01/01/1981 - "The decubitus ulcers of 4 patients being treated with dextranomer for up to three months were examined. " 01/01/1981 - "The use of dextranomer in decubitus ulcers: a histopathologic evaluation." 04/01/1979 - "Debrisan for decubitus ulcers." 08/17/1978 - "Debrisorb represent an essential help in the treatment of pressure sores. " Order ALL the reference details at left...
6.	Collagenases (Collagenase)FDA Link 05/01/1975 - "Collagenase therapy for decubitus ulcers." 01/01/1975 - "Collagenase in the treatment of dermal and decubitus ulcers." 01/01/2001 - "OBJECTIVE: To evaluate the efficacy and cost effectiveness of two treatments of pressure sores on the heel: a collagenase-containing ointment and a hydrocolloid dressing. " 01/01/2001 - "Economic evaluation of collagenase-containing ointment and hydrocolloid dressing in the treatment of pressure ulcers." 08/01/1975 - "Hydrotherapy and topical collagenase for decubitus ulcers." Order ALL the reference details at left...
7.	platelet-derived growth factor BB (becaplermin)FDA Link 05/01/1999 - "In this study, the efficacy of becaplermin gel in the treatment of chronic full thickness pressure ulcers was compared with that of placebo gel. " 02/01/1994 - "OBJECTIVE: To determine the efficacy of the daily topical application of recombinant platelet-derived growth factor-BB (rPDGF-BB), a recognized vulnerary agent, in the treatment of deep pressure ulcers. " 05/01/1999 - "Becaplermin gel in the treatment of pressure ulcers: a phase II randomized, double-blind, placebo-controlled study." 12/01/1994 - "In a double-blinded trial, patients having chronic pressure ulcers were treated topically with either rPDGF-BB or placebo for 28 days. " 02/01/1994 - "CONCLUSIONS: Data from this small trial suggest that local application of rPDGF-BB may be of therapeutic benefit in accelerating the healing of chronic pressure ulcers." Order ALL the reference details at left...
8.	Arginine (L-Arginine)FDA Link 09/01/2000 - "The purpose of this study was to determine what level of arginine supplementation was orally and metabolically tolerated and effective in enhancing immune function in elderly persons with pressure ulcers. " 04/01/2005 - "Twenty-six elders, 65 years of age or older, with one or more pressure ulcers, were randomized to receive 8.5 g of arginine or an isonitrogenous supplement for 4 weeks. " 01/01/2001 - "Impact on pressure ulcer healing of an arginine-enriched nutritional solution in patients with severe cognitive impairment." 08/01/2009 - "Nutritional support in the treatment and prevention of pressure ulcers: an overview of studies with an arginine enriched oral nutritional supplement." 09/01/2000 - "Arginine supplementation is well tolerated but does not enhance mitogen-induced lymphocyte proliferation in elderly nursing home residents with pressure ulcers." Order ALL the reference details at left...
9.	PolymersIBA 08/01/1998 - "There was a significant reduction in the odds of developing a pressure sore on the dry visco-elastic polymer pad as compared to the standard, [symbol see text] = 0.46 with 95% confidence interval of (0.26, 0.82), P = 0.010. " 08/12/1999 - "This study examined a way to redress the balance through use of an alternative, cost-effective type of mattress (thermoelastic polymer) in the prevention of pressure sores. " 08/01/1998 - "Four hundred and forty-six general, vascular and gynaecological surgical patients were recruited to a two centre, double triangular sequential randomised controlled trial to compare the post-operative pressure sore incidence in patients positioned on the standard operating table mattress with those positioned on the dry visco-elastic polymer pad (Action Products Inc.). " 08/01/1998 - "A sequential randomised controlled trial comparing a dry visco-elastic polymer pad and standard operating table mattress in the prevention of post-operative pressure sores." 04/01/2005 - "Electric profiling beds with a visco-elastic polymer mattress are a new innovation in pressure ulcer prevention; however, mattress efficacy is reduced by tightly tucking sheets around the mattress. " Order ALL the reference details at left...
10.	Insulin (Novolin)FDA Link 01/01/1976 - "To test the hypothesis that there will be a significantly greater increase in the rate of healing of decubitus ulcers in subjects who receive topical insulin therapy than in subjects who receive other forms of therapy, a pilot study was conducted, utilizing a two-group before and after design. " 01/01/1976 - "Although generalizations cannot be based on the results of 14 subjects, data analysis showed that insulin was a safe and effective agent in the healing of small, uncomplicated decubitus ulcers. " 05/05/1994 - "[Study on close insulin wet compresses in treating bedsores]" 01/01/1979 - "When a pilot study provided evidence that insulin may increase the rate of healing of decubitus ulcers, this study attempted to answer the question: Is topical insulin therapy an effective treatment regimen for decubitus ulcers? " 06/01/1981 - "Topical application of insulin to pressure sores: a questionable therapy." Order ALL the reference details at left...

Therapies and Procedures

1.	Debridement 03/01/1999 - "OBJECTIVE: To compare the clinical efficacy of 4 debridement alternatives in pressure ulcer management. " 01/01/2008 - "RESULTS: The resulting trochanteric defects in this study were due to debridement of pressure sore. " 01/01/1996 - "These results combined with data from previous studies suggest that patients not receiving PRT developed severe pressure ulcers which required debridement surgery and healed more slowly due, in part, to reduced levels of CAMs." 07/01/2009 - "Operative debridement of pressure ulcers." 04/01/2007 - "Pressure ulcers with undermined edges are generally hard to treat and may require surgical debridement and flap coverage. " Order ALL the reference details at left...
2.	Hydrocolloid Bandages (Duoderm) 07/01/1990 - "DuoDERM application and prosthetic socket modification have been found useful for the treatment of decubitus ulcers in ambulatory patients. " 04/01/2009 - "Hydrocolloid dressing may help to increase the healing rate of pressure ulcers." 06/01/1987 - "Improved pressure sore healing with hydrocolloid dressings." 06/01/1999 - "Forty adult patients of both sexes who had Stage II or III pressure ulcers (according to the Agency for Health Care Policy and Research system) were enrolled in the study and were randomized to either the hydrocellular or hydrocolloid dressing. " 06/01/1999 - "This study compared an adhesive hydrocellular dressing with a leading hydrocolloid dressing in the management of pressure ulcers. " Order ALL the reference details at left...
3.	Long-Term Care 11/01/1994 - "3. Strategies that are effective in reducing both the development and severity of pressure ulcers can be successfully implemented in long-term care settings. " 12/10/2008 - "Among 7 RCTs evaluating nutritional supplements, 1 higher-quality trial found that protein supplementation of long-term care residents improved wound healing compared with placebo (improvement in Pressure Ulcer Scale for Healing mean [SD] score of 3.55 [4.66] vs 3.22 [4.11], respectively; P < .05). " 03/01/1996 - "CONCLUSION: The use of aggressive preventive measures in the long-term care setting is effective in reducing pressure ulcers and requires a relatively low level of institutional expenditures." 11/01/2008 - "AIMS: This study examined the associations between nurse working conditions (time pressure and perceived unfair management) and quality indicators (prevalence of antianxiety or hypnotic drug use and pressure ulcers) in long-term care units. " 07/01/2008 - "SETTING: One hundred two nursing homes participating in the National Pressure Ulcer Long-Term Care Study (NPULS) in the United States. " Order ALL the reference details at left...
4.	Skin Care 10/01/2006 - "This project improved skin care quality and reduced pressure ulcer complications. " 01/01/1995 - "Individual programs for skin care and routine assessment with a pressure sore prediction instrument, such as the MNS, would serve the dual purpose of directing the relevant measures to the patient groups at the greatest risk and would aid in assessing the efficacy of pressure sore treatment strategies." 10/01/2007 - "An overview of research studies relevant to telemedicine and neuromuscular electrical stimulation in the care and prevention of pressure ulcers as well as preliminary results of an innovative multidisciplinary skin care team approach to the primary and tertiary prevention of pressure ulcers are encouraging. " 04/01/2004 - "[Study of incidence of decubitus ulcer: skin care with effectiveness]" 03/01/1995 - "Pressure sores and incontinence: a study evaluating the use of topical agents in skin care." Order ALL the reference details at left...
5.	Phototherapy (Light Therapy) 12/01/2007 - "Monochromatic phototherapy: effective treatment for grade II chronic pressure ulcers in elderly patients." 10/01/2004 - "Efficacy of multiwavelength light therapy in the treatment of pressure ulcers in subjects with disorders of the spinal cord: A randomized double-blind controlled trial." 12/01/2008 - "The aim of this study was to establish the effects of polarized light therapy in pressure ulcer healing. " 01/01/1990 - "Ultraviolet (UV) light therapy has been suggested as a treatment for pressure sores and crural ulcerations even though controlled trials are few. " 12/01/2008 - "The effects of polarized light therapy in pressure ulcer healing." Order ALL the reference details at left...

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