HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

The Long (lncRNA) and Short (miRNA) of It: TGFβ-Mediated Control of RNA-Binding Proteins and Noncoding RNAs.

Abstract
RNA-binding proteins (RBP) and noncoding RNAs (ncRNA), such as long noncoding RNAs (lncRNA) and microRNAs (miRNA), control co- and posttranscriptional gene regulation (PTR). At the PTR level, RBPs and ncRNAs contribute to pre-mRNA processing, mRNA maturation, transport, localization, turnover, and translation. Deregulation of RBPs and ncRNAs promotes the onset of cancer progression and metastasis. Both RBPs and ncRNAs are altered by signaling cascades to cooperate or compete with each other to bind their nucleic acid targets. Most importantly, transforming growth factor-beta (TGFβ) signaling plays a significant role in controlling gene expression patterns by targeting RBPs and ncRNAs. Because of TGFβ signaling in cancer, RBP-RNA or RNA-RNA interactions are altered and cause enhanced cell growth and tumor cell dissemination. This review focuses on the emerging concepts of TGFβ signaling on posttranscriptional gene regulation and highlights the implications of RBPs and ncRNAs in cancer progression and metastasis. Mol Cancer Res; 16(4); 567-79. ©2018 AACR.
AuthorsHarinarayanan Janakiraman, Reniqua P House, Vamsi K Gangaraju, J Alan Diehl, Philip H Howe, Viswanathan Palanisamy
JournalMolecular cancer research : MCR (Mol Cancer Res) Vol. 16 Issue 4 Pg. 567-579 (04 2018) ISSN: 1557-3125 [Electronic] United States
PMID29555893 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
Copyright©2018 American Association for Cancer Research.
Chemical References
  • MicroRNAs
  • RNA, Long Noncoding
  • RNA-Binding Proteins
  • Transforming Growth Factor beta
Topics
  • Animals
  • Disease Progression
  • Gene Expression Regulation, Neoplastic
  • Humans
  • MicroRNAs (genetics)
  • Neoplasm Metastasis
  • Neoplasms (genetics, metabolism)
  • RNA Processing, Post-Transcriptional
  • RNA, Long Noncoding (genetics)
  • RNA-Binding Proteins (genetics)
  • Signal Transduction
  • Transforming Growth Factor beta (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: