Copper Silicate Hollow Microspheres-Incorporated Scaffolds for Chemo-Photothermal Therapy of Melanoma and Tissue Healing.

Abstract

The treatment of melanoma requires complete removal of tumor cells and simultaneous tissue regeneration of tumor-initiated cutaneous defects. Herein, copper silicate hollow microspheres (CSO HMSs)-incorporated bioactive scaffolds were designed for chemo-photothermal therapy of skin cancers and regeneration of skin tissue. CSO HMSs were synthesized with interior hollow and external nanoneedle microstructure, showing excellent drug-loading capacity and photothermal effects. With incorporation of drug-loaded CSO HMSs into the electrospun scaffolds, the composite scaffolds exhibited excellent photothermal effects and controlled NIR-triggered drug release, leading to distinctly synergistic chemo-photothermal therapy of skin cancer both in vitro and in vivo. Furthermore, such CSO HMSs-incorporated scaffolds could promote proliferation and attachment of normal skin cells and accelerate skin tissue healing in tumor-bearing and diabetic mice. Taken together, CSO HMSs-incorporated scaffolds may be used for complete eradication of the remaining tumor cells after surgery and simultaneous tissue healing, which offers an effective strategy for therapy and regeneration of tumor-initiated tissue defects.

• Authors: Qingqing Yu, Yiming Han, Xiaocheng Wang, Chen Qin, Dong Zhai, Zhengfang Yi, Jiang Chang, Yin Xiao, Chengtie Wu
• Journal: ACS nano (ACS Nano) Vol. 12 Issue 3 Pg. 2695-2707 (03 27 2018) ISSN: 1936-086X [Electronic] United States
• PMID: 29518321 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Drug Carriers
• Pyridones
• Pyrimidinones
• Silicates
• copper silicate
• trametinib
• Copper

Topics

• Animals
• Antineoplastic Agents (administration & dosage, therapeutic use)
• Cell Line, Tumor
• Copper (chemistry, therapeutic use)
• Drug Carriers (chemistry, therapeutic use)
• Drug Delivery Systems
• Hyperthermia, Induced (methods)
• Male
• Melanoma (pathology, therapy)
• Mice, Inbred BALB C
• Mice, Nude
• Nanostructures (chemistry, therapeutic use)
• Phototherapy (methods)
• Pyridones (administration & dosage, therapeutic use)
• Pyrimidinones (administration & dosage, therapeutic use)
• Silicates (chemistry, therapeutic use)
• Skin Neoplasms (pathology, therapy)
• Tissue Scaffolds (chemistry)