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Rig-I is involved in inflammation through the IPS-1/TRAF6 pathway in astrocytes under chemical hypoxia.

Abstract
The retinoic acid-inducible gene I (RIG-I) is a crucial cytoplasmic pathogen recognition receptor involved in neuroinflammation in degenerative diseases. In the present study, in vitro human astrocytes were subjected to a chemical hypoxia model using cobalt chloride pretreatment. Chemical hypoxia induces the up-regulation of RIG-I in astrocytes and results in the expression of inflammatory cytokines IL-1β, IL-6, and TNF-α in an NF-κB dependent manner. Elevated RIG-I modulates the interaction of interferon-β promoter stimulator-1 (IPS-1) and TNF receptor-associated factor 6 (TRAF6) following chemical hypoxia. Inhibition of IPS-1 or TRAF6 suppresses RIG-I-induced NF-κB activation and inflammatory cytokines in response to chemical hypoxia. These data suggest that chemical hypoxia leads to RIG-I activation and the expression of inflammatory cytokines through the NF-κB pathway. Blocking IPS-1/TRAF6 pathway relieves RIG-I-induced neuroinflammation in astrocytes subjected to hypoxia.
AuthorsLei Li, Rongli Yang, Meijiang Feng, YiChen Guo, YuXuan Wang, Jun Guo, Xiang Lu
JournalNeuroscience letters (Neurosci Lett) Vol. 672 Pg. 46-52 (04 13 2018) ISSN: 1872-7972 [Electronic] Ireland
PMID29474875 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2018 Elsevier B.V. All rights reserved.
Chemical References
  • Adaptor Proteins, Signal Transducing
  • MAVS protein, human
  • Receptors, Immunologic
  • TNF Receptor-Associated Factor 6
  • Cobalt
  • DDX58 protein, human
  • DEAD Box Protein 58
  • cobaltous chloride
Topics
  • Adaptor Proteins, Signal Transducing (metabolism)
  • Astrocytes (drug effects, metabolism)
  • Cell Hypoxia (drug effects, physiology)
  • Cell Line, Tumor
  • Cobalt (pharmacology)
  • DEAD Box Protein 58 (metabolism)
  • Humans
  • Inflammation (metabolism)
  • Receptors, Immunologic
  • Signal Transduction (drug effects)
  • TNF Receptor-Associated Factor 6 (metabolism)
  • Up-Regulation

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