Toll-like receptor variants and cervical Atopobium vaginae infection in women with pelvic inflammatory disease.

Abstract

PROBLEM:

Toll-like (TLR) receptor genetic variants have been implicated in bacterial vaginosis (BV). We determined whether TLR variants are associated with fastidious BV-associated microbes that are linked with infertility following pelvic inflammatory disease (PID).

METHOD OF STUDY:

Sneathia spp., Atopobium vaginae, BVAB1, and Ureaplasma urealyticum were measured in 250 women from the PID Evaluation and Clinical Health (PEACH) study. Relative risk (RR) and 95% confidence intervals (CI) were calculated adjusting for chlamydia and gonorrhea. Principal component analysis was used to adjust for population stratification. A false discovery rate q-value of 0.05 was significant.

RESULTS:

TLR2-1733C>A (P = .003) and TLR2-616A>G (P = .004) were associated with cervical A. vaginae. TLR2-1733C>A and TLR6-438C>T were associated with A. vaginae detection in the endometrium, but this was not significant after adjustment for multiple comparisons (FDR q-value = 0.06).

CONCLUSION:

Host gene variants in TLR2 signaling pathways were modestly associated with cervical A. vaginae in women with clinical PID.

• Authors: Brandie D Taylor, Patricia A Totten, Sabina G Astete, Michael J Ferris, David H Martin, Roberta B Ness, Catherine L Haggerty
• Journal: American journal of reproductive immunology (New York, N.Y. : 1989) (Am J Reprod Immunol) Vol. 79 Issue 2 (02 2018) ISSN: 1600-0897 [Electronic] Denmark
• PMID: 29286178 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
• Copyright: © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• TLR2 protein, human
• Toll-Like Receptor 2
• Toll-Like Receptors

Topics

• Adolescent
• Adult
• Corynebacterium (physiology)
• Corynebacterium Infections (genetics, immunology)
• Cross-Sectional Studies
• Endometrium (immunology, microbiology)
• Female
• Genetic Predisposition to Disease
• Genotype
• Humans
• Polymorphism, Single Nucleotide
• Principal Component Analysis
• Risk
• Signal Transduction
• Toll-Like Receptor 2 (genetics)
• Toll-Like Receptors (genetics)
• Vaginosis, Bacterial (genetics, immunology)
• Young Adult