Gonorrhea

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1492 relevant articles (116 outcomes, 144 trials/studies) found for this Disease

Description: Acute infectious disease characterized by primary invasion of the urogenital tract. The etiologic agent, NEISSERIA GONORRHOEAE, was isolated by Neisser in 1879.

Also Known As:

Gonorrheas

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Infection
2.	Sexually Transmitted Diseases (Sexually Transmitted Disease)
3.	Syphilis
4.	Urinary Tract Infections (Urinary Tract Infection)
5.	Chancroid

Experts

1.	Warner, Lee: 4 articles (02/2008 - 02/2004)
2.	Douglas, John M: 2 articles (02/2008 - 02/2004)
3.	Bolan, Gail: 2 articles (02/2008 - 02/2004)
4.	Kamb, Mary L: 2 articles (02/2008 - 02/2004)
5.	Project RESPECT Study Group: 2 articles (02/2008 - 02/2004)
6.	Fishbein, Martin: 2 articles (02/2008 - 02/2004)
7.	Rogers, Judy: 2 articles (02/2008 - 02/2004)
8.	Newman, Daniel R: 2 articles (02/2008 - 02/2004)
9.	Macaluso, Maurizio: 2 articles (01/2006 - 02/2004)
10.	Austin, Harland D: 2 articles (01/2006 - 02/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Gonorrhea:

1.	Penicillins (Penicillin)FDA Link 01/01/1984 - " This study evaluates the efficacy of TAP compared with the standard regimen of Aqueous Procain Penicillin + Probenicid in the treatment of uncomplicated genital gonorrhea in men in Central African Republic. " 01/01/2005 - "The ethical dilemma of inducing a disease with an unpredictable outcome persisted until the 1940s, when gonorrhea could be reliably cured by penicillin." 09/01/1980 - "The efficacy of penicillin regimen in treatment of women with culture positive gonorrhea." 12/01/1975 - "[Is there a possibility for gonorrhea patients who cured themselves with peroral penicillin to escape medical evidence]" 08/01/1986 - "Unique strains of Neisseria gonorrhoeae causing epidemic gonorrhea during the penicillin era: a study of isolates from Denmark." Order ALL the reference details at left...
2.	Ceftriaxone (Ceftriaxon)FDA LinkGeneric 08/01/1995 - "Our data suggest that most prepubertal children with gonorrhea are symptomatic at initial presentation and are cured after recommended treatment with ceftriaxone. " 07/01/1989 - "The Centers for Disease Control now recommends ceftriaxone for the first line treatment of gonorrhea but there are no data as to its use in children for this indication. " 10/01/1987 - "We retrospectively analyzed the efficacy of ceftriaxone in a single dose of 125 mg given intramuscularly for treatment of uncomplicated gonorrhea. " 10/01/1987 - "These results confirm those of earlier clinical trials showing that 125 mg of ceftriaxone is effective therapy for uncomplicated gonorrhea in a geographic area with a high prevalence of gonococci with chromosomally mediated antibiotic resistance." 12/01/1981 - "Dose-ranging study of ceftriaxone for uncomplicated gonorrhea in men." Order ALL the reference details at left...
3.	Probenecid (Benemid)FDA LinkGeneric 04/01/1989 - "Therefore, the combination of epiciline-probenecid is a valid alternative for routine treatment of acute uncomplicated gonorrhea." 04/01/1989 - "We treated 142 patients with acute uncomplicated gonorrhea with a single oral dose of epiciline-probenecid. " 09/05/1968 - "[Gonorrhea therapy with a combination of probenecid and benzylsodiumpenicillin. " 01/01/1976 - "To monitor the efficacy of the 1972 United States Public Health Service recommended treatment regimens for uncomplicated gonorrhea, we studied 9008 patients who were randomly assigned either to aqueous procaine penicillin G, 4.8 million units intramuscularly plus 1 g of oral probenecid, or to one of the three other recommended regimens. " 08/01/1986 - "Cefuroxime axetil alone is effective for urethral gonorrhea in males; rectal gonorrhea probably requires additional probenecid." Order ALL the reference details at left...
4.	Ciprofloxacin (Cipro)FDA LinkGeneric 08/01/1986 - "A single 0.25-g dose of ciprofloxacin was effective for treatment of uncomplicated urethral gonorrhea in men, but it did not eradicate coinfection with C. " 07/01/1986 - "Comparative clinical efficacy of two different single-dose ciprofloxacin treatments for uncomplicated gonorrhea." 03/15/2001 - "Although ciprofloxacin is one of the recommended drugs of choice for the treatment of gonorrhea, in vitro resistance to this drug has been observed in surveillance studies and case reports from many parts of the world, including Bangladesh. " 01/01/2008 - "The gonorrhea prevalence in MSM and heterosexual men was 0.091(91/1000) and the Neisseria gonorrhoeae ciprofloxacin resistant (CRNG) was 20% in MSM and 3.8% in heterosexual men (p: 0.0416). " 04/01/2007 - "We tested 96 urine samples collected along with Gonorrhea Isolate Surveillance Project (GISP) urethral swab samples and compared the results with matched MICs of ciprofloxacin, as reported by the regional GISP laboratory. " Order ALL the reference details at left...
5.	Nonoxynol (Nonoxynol 9)FDA Link 08/01/2005 - "OBJECTIVES: To understand why clinical trials failed to demonstrate efficacy of nonoxynol-9 in preventing gonorrhea. " 06/01/1994 - "The use of nonoxynol-9 for protection against cervical gonorrhea." 10/01/1998 - "The first "real-life" controlled trial of the spermicide Nonoxynol 9 (N-9) has indicated that N-9 may be ineffective in reducing rates of HIV, gonorrhea, or chlamydia. " 01/01/1997 - "A 2-year Family Health International (FHI) study concluded that a spermicidal film containing nonoxynol-9 (N-9) is safe, but does not provide any additional protection for women against HIV, gonorrhea, or chlamydia. " 07/01/2001 - "There was a significantly higher incidence of gonorrhea in the nonoxynol-9 group than in the placebo group. " Order ALL the reference details at left...
6.	Spectinomycin (Spectinomycin Hydrochloride)FDA Link 01/01/1982 - "Spectinomycin is a broad-spectrum aminocyclitol antibiotic that is highly effective in the treatment of uncomplicated gonorrhea. " 09/01/1976 - "Spectinomycin clinically has been proven to be highly effective in the intramuscular single-dose treatment of gonorrhea. " 09/01/1976 - "The present study suggests that administration of spectinomycin at the dose levels recommended for single-dose treatment of gonorrhea (2 or 4 g) most probably is free from ototoxic effect." 09/01/1976 - "According to NOVAK et al. (1974), all evidence from pharmacological and clinical efficacy studies to date indicates that spectinomycin is free from ototoxic effects at the dose levels recommended for single-dose treatment of gonorrhea (2 or 4 g) or repeated i.m. " 01/01/1993 - "[Effectiveness of trobicin (spectinomycin) effectiveness in acute gonorrhea of men]" Order ALL the reference details at left...
7.	Ofloxacin (Levofloxacin)FDA LinkGeneric 01/01/1990 - "In a study of single-dose ofloxacin treatment of uncomplicated gonorrhea, Neisseria gonorrhoeae was eradicated in all subjects, but C. " 09/01/1993 - "This trend of decreasing susceptibility warrants close monitoring when ofloxacin is used as first-line treatment for gonorrhea." 12/29/1989 - "Single-dose efficacy of ofloxacin in uncomplicated gonorrhea." 06/01/2003 - "On the basis of the presumptive clinical diagnosis of gonorrhea because of the microscopic detection of diplococci in the urethral discharge, he was treated with levofloxacin (300 mg per day) for 7 days. " 05/01/1997 - "RESULTS: Treatment failure with multiple doses of ofloxacin was observed in this case of gonorrhea. " Order ALL the reference details at left...
8.	Ampicillin (Omnipen)FDA LinkGeneric 10/01/1979 - "[Ampicillin treatment trial in gonorrhea recurrences]" 08/01/1976 - "[Study of the effectiveness of ampicillin in the therapy of fresh gonorrhea in men and women]" 04/01/1988 - "Treatment of pharyngeal gonorrhea with extended oral ampicillin." 10/01/1979 - "The clinical and laboratory investigations showed high efficiency of ampicillin in treatment of gonorrhea relapses. " 10/01/1979 - "Etiological recovery was recorded in all the gonorrhea patients due to the treatment with ampicillin. " Order ALL the reference details at left...
9.	Cefixime (Suprax)FDA Link 01/01/1997 - ": A single 400 mg oral dose of cefixime was effective for the treatment of gonorrhea and was well tolerated by the pregnant women." 09/01/1993 - "BACKGROUND: Single-dose cefixime 400 mg orally is effective in the treatment of uncomplicated gonorrhea. " 08/01/1993 - "Single-dose oral treatment with cefixime (Suprax) or a quinolone appears to be effective, safe, and practical for patients with uncomplicated gonorrhea. " 01/01/1997 - "Open study of the safety and efficacy of a single oral dose of cefixime for the treatment of gonorrhea in pregnancy." 09/01/1993 - "OBJECTIVE: To assess the efficacy of 200 mg cefixime in the treatment of uncomplicated gonorrhea. " Order ALL the reference details at left...
10.	Azithromycin (Zithromax)FDA LinkGeneric 11/01/1998 - "GOAL OF THIS STUDY: To examine gonococci not eliminated with 1 g azithromycin therapy to establish treatment outcome/MIC correlates in gonorrhea. " 03/01/1994 - "Azithromycin Gonorrhea Study Group." 08/01/2006 - "Pharyngeal Gonorrhea in female sex workers: Response to a single 2-g dose of azithromycin." 11/01/1998 - "CONCLUSION: The antibiotic MIC/treatment outcome correlates that are usually found in gonorrhea do not apply for azithromycin. " 11/01/1998 - "Failure of azithromycin therapy in gonorrhea and discorrelation with laboratory test parameters." Order ALL the reference details at left...

Therapies and Procedures

1.	Condoms (Condom) 02/01/2004 - "Among 429 participants with known Gc/Ct exposure, consistent condom use was associated with a significant reduction in prevalent gonorrhea and chlamydia (30% vs. 43%; adjusted prevalence odds ratio = 0.42, 95% confidence interval: 0.18, 0.99). " 08/01/1995 - " Furthermore, condom use in a core group is more effective than condom use in the non-core group for reducing the prevalence of gonorrhea and HIV. " 09/01/2001 - "Special NIH review confirms condoms effective against transmission of HIV, gonorrhea." 11/09/2001 - "Irregular condom use was not protective against HIV or STD and was associated with increased gonorrhea/Chlamydia risk (OR, 1.44; 95% CI, 1.06-1.99). " 03/01/1999 - "This study was undertaken to evaluate the efficacy of condoms and vaginal spermicide products, used alone or in combination, in preventing gonorrhea and chlamydia among women attending an STD clinic. " Order ALL the reference details at left...
2.	Female Contraceptive Devices (Vaginal Ring) 09/01/1990 - " Diaphragms, cervical caps, and vaginal sponges provide some protection against infections like gonorrhea and chlamydiae that invade the cervical cells. " 01/01/1987 - " A study conducted in Thailand found that the use of vaginal sponges impregnated with nonoxynol-9 significantly reduced the rates of chlamydia and gonorrhea among prostitutes. " Order ALL the reference details at left...
3.	Gynecologic Surgical Procedures (Gynecologic Surgery) 07/01/1988 - "Clinical studies to date have also shown the combination to be effective for the treatment of meningitis, pneumonia, gonorrhea, epiglottis, urinary tract infections, cervical adenitis, and as prophylaxis for abdominal and gynecological surgeries. " Order ALL the reference details at left...
4.	Aftercare (After-Treatment) 10/01/1982 - "Test-of-cure cultures for patients who were asymptomatic after treatment for gonorrhea required the expenditure of from $4,900 to $109,800 for each case of asymptomatic persistent gonorrhea discovered and cured, depending on the strategy used." 08/01/2009 - "Determining the magnitude of chlamydia and gonorrhea reinfection is critical to inform evidence-based clinical practice guidelines related to retesting after treatment. " 10/01/2007 - "PGU was judged to be present if the urethral smear was positive for polymorphonuclear leucocytes 7-14 days after treatment for gonorrhea. " 11/01/2004 - "GOAL: We compared various methods of encouraging return for retesting 3 months after treatment for chlamydia or gonorrhea. " 11/01/2004 - "BACKGROUND: Retesting 3 to 4 months after treatment for those infected with chlamydia and/or gonorrhea has been recommended. " Order ALL the reference details at left...
5.	Drug Therapy (Chemotherapy) 11/18/1972 - "Chemotherapy of gonorrhea: a review of current status." 09/01/1954 - "Chemotherapy of gonorrhea; clinical observation in 201 cases." 01/01/1945 - "The Chemotherapy of Gonorrhea." 01/01/1973 - "Spectinomycin related to the chemotherapy of gonorrhea." 02/14/1957 - "[Side-effects of antibiotics and the masking of gonorrhea symptoms by chemotherapy and antibiotics.]" Order ALL the reference details at left...

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