Bacterial Vaginosis

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666 relevant articles (93 outcomes, 143 trials/studies) found for this Disease

Description: Polymicrobial, nonspecific vaginitis associated with positive cultures of Gardnerella vaginalis and other anaerobic organisms and a decrease in lactobacilli. It remains unclear whether the initial pathogenic event is caused by the growth of anaerobes or a primary decrease in lactobacilli.

Also Known As:

Vaginosis, Bacterial; Bacterial Vaginitides; Bacterial Vaginitis; Bacterial Vaginoses; Vaginitides, Bacterial; Vaginoses, Bacterial; Nonspecific Vaginitis; Vaginitis, Bacterial; Vaginitis, Nonspecific

Relationship Network

Disease Context: Research Results

Bacterial Infections and Mycoses

Bacterial Infections: 6830

Bacterial Vaginosis: 666

Female Urogenital Diseases and Pregnancy Complications

Female Urogenital Diseases

Female Genital Diseases: 189

Vaginal Diseases: 16

Vaginitis: 687

Bacterial Vaginosis: 666

Related Diseases

1.	Infection
2.	Premature Birth (Birth, Premature)
3.	Vaginitis
4.	Candidiasis (Moniliasis)
5.	Syphilis

Experts

1.	Hillier, Sharon L: 9 articles (01/2008 - 10/2002)
2.	Cauci, Sabina: 7 articles (01/2008 - 05/2002)
3.	Nyirjesy, Paul: 6 articles (08/2007 - 11/2004)
4.	Guaschino, Secondo: 5 articles (12/2007 - 05/2002)
5.	Hillier, S L: 4 articles (09/2005 - 02/2000)
6.	Quadrifoglio, Franco: 4 articles (01/2003 - 05/2002)
7.	Reid, Gregor: 3 articles (05/2008 - 05/2006)
8.	Meyn, Leslie A: 3 articles (01/2008 - 05/2005)
9.	De Santo, Davide: 3 articles (12/2007 - 06/2002)
10.	Brocklehurst, P: 3 articles (01/2007 - 01/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Bacterial Vaginosis:

1.	Metronidazole (Metric)FDA LinkGeneric 07/01/2000 - "CONCLUSION: Most patients with odor had bacterial vaginosis and had an improvement in odor with topical metronidazole. " 04/01/1999 - "CONCLUSION: The most cost-effective treatment for bacterial vaginosis was generic metronidazole. " 07/01/1990 - "Metronidazole (500 mg twice daily for 7 days) continues to be highly efficacious in the treatment of bacterial vaginosis. " 12/01/2008 - "Intravaginally applied metronidazole is as effective as orally applied in the treatment of bacterial vaginosis, but exhibits significantly less side effects." 03/10/1991 - "Mobiluncus associated bacterial vaginosis can be treated successfully with 500 mg of metronidazole three times a day for seven days." Order ALL the reference details at left...
2.	Clindamycin (Cleocin)FDA LinkGeneric 08/01/1995 - "Of the 80 patients who were recorded "success" or "improved" at visit 2, 20 (25%) were reported to have a "recurrence" of BV at Visit 3. The meta-analysis on those who were evaluable at Visit 2 and 3 also showed that clindamycin cream 2% was an effective treatment for bacterial vaginosis, and the differences between the clindamycin group and the placebo group were statistically significant. " 11/01/1994 - "RESULTS: Clindamycin eradicated and/or decreased counts of major bacterial vaginosis-associated microflora such as Gardnerella, gram-negative and gram-positive anaerobes, and Mycoplasma hominis; this was correlated with cure in 22 of 24 (92%) women. " 08/01/1995 - "CONCLUSION--We conclude that a 3 day course of clindamycin 2% cream is an effective, and well tolerated treatment for bacterial vaginosis." 11/01/1994 - "CONCLUSION: Microbial (and clinical) results support use of clindamycin as effective treatment of bacterial vaginosis." 11/01/1993 - "CONCLUSIONS: Intravaginal clindamycin 2% cream appears to be an effective and safe treatment of symptomatic bacterial vaginosis in nonpregnant women." Order ALL the reference details at left...
3.	Vaginal Creams, Foams, and Jellies (Vaginal Tablet)IBA 06/01/2005 - "OBJECTIVE: We evaluated the efficacy of a mucoadhesive vaginal gel (MVG, Miphil) with acidic-buffering properties in bacterial vaginosis (BV). " 01/01/2009 - "The purpose of this study was to determine the effectiveness of Lactobacillus-containing vaginal tablets in the treatment of bacterial vaginosis (BV) and in the restoration of a healthy vaginal flora. " 04/01/1994 - "Within this study, women with bacterial vaginosis (16 to 27 week' gestation) were treated with 2% clinadmycin vaginal cream or placebo. " 01/01/2009 - "Effectiveness of Lactobacillus-containing vaginal tablets in the treatment of symptomatic bacterial vaginosis." 11/01/2005 - "Recurrent bacterial vaginosis: the use of maintenance acidic vaginal gel following treatment." Order ALL the reference details at left...
4.	Tinidazole FDA Link 02/20/1991 - "Although there were no statistically significant differences between the two groups with respect to clinical effect and tolerance, the results do show that, for the treatment of bacterial vaginosis, a single dose of tinidazole represents a clinically effective and well-tolerated therapy that is minimally stressful for the patient and is particularly suitable for prescription by the practicing physician." 08/01/2007 - "CONCLUSION: Both tinidazole regimens studied provided effective treatment for bacterial vaginosis. " 02/01/2009 - "Improved cure of bacterial vaginosis with single dose of tinidazole (2 g), Lactobacillus rhamnosus GR-1, and Lactobacillus reuteri RC-14: a randomized, double-blind, placebo-controlled trial." 10/01/1993 - "A randomized double-blind trial of tinidazole treatment of the sexual partners of females with bacterial vaginosis." 09/01/1983 - "Oral tinidazole, 500 mg twice daily for 5 days, was compared to triple sulfonamide cream inserted into the vagina twice daily for 7 days for the treatment of nonspecific vaginitis in a placebo-controlled, double-blind trial. " Order ALL the reference details at left...
5.	Erythromycin (Erycette)FDA LinkGeneric 11/01/1979 - "To assess the efficacy of oral erythromycin in the treatment of nonspecific vaginitis (NSV), conducted a nonrandom, unblinded pilot study among 17 women with symptoms and signs of NSV. " 07/01/1996 - "Reduced incidence of preterm delivery with metronidazole and erythromycin in women with bacterial vaginosis." 12/28/1995 - "Reduced incidence of preterm delivery with metronidazole and erythromycin in women with bacterial vaginosis." 09/01/1998 - "Two trials with use of metronidazole (alone or with erythromycin) showed a reduction in preterm delivery in women who were at a high risk of preterm delivery and had bacterial vaginosis at screening. " 12/28/1995 - "Treatment with metronidazole and erythromycin reduced rates of premature delivery in women with bacterial vaginosis and an increased risk for preterm delivery." Order ALL the reference details at left...
6.	Fibronectins (Fibronectin)IBA 08/01/2000 - "STUDY DESIGN: Vaginal fetal fibronectin was quantitatively determined in a prospective cohort study of 13,360 women being evaluated for participation in the National Institute of Child Health and Human Development Maternal-Fetal Medicine Unit treatment trials for bacterial vaginosis and Trichomonas vaginalis. " 12/01/2005 - "The other infectious markers tested were: bacterial vaginosis and fetal fibronectin in cervical secretions; serum CRP and white blood cell count. " 06/01/2004 - "RESULTS: These women comprised 4 groups: group A (n=23 women; +bacterial vaginosis/+fetal fibronectin); group B (n=31 women; -bacterial vaginosis/+fetal fibronectin); group C (n=47 women; +bacterial vaginosis/-fetal fibronectin); and group D (n=84 women; -bacterial vaginosis/-fetal fibronectin). " 06/01/2002 - "At 20 and 24 weeks of gestation, screening for bacterial vaginosis and fetal fibronectin was performed, followed by digital and sonographic assessment of the cervix. " 12/01/2000 - "Fetal fibronectin was positive in 4% of their samples and was found to be twice as likely in one with bacterial vaginosis. " Order ALL the reference details at left...
7.	secnidazoleIBA 03/01/2005 - "OBJECTIVE: To determine whether bacterial vaginosis could be cured with a single 1-g oral dose of secnidazole. " 03/01/2005 - "CONCLUSION: This clinical study showed that a single 1-g oral dose of secnidazole is effective to cure bacterial vaginosis associated with G. " 03/01/2005 - "Low-dose secnidazole in the treatment of bacterial vaginosis." 01/08/2009 - "Secnidazole (alpha,2-dimethyl-5-nitro-1H-imidazole-1-ethanol) is an antimicrobical drug, and it is particularly effective in the treatment of amebiasis, giardiasis, trichomoniasis, and bacterial vaginosis. " 04/01/1996 - "In summary, available evidence suggests that secnidazole is as efficacious as other 5-nitroimidazole drugs in the treatment of protozoal infections and bacterial vaginosis. " Order ALL the reference details at left...
8.	Povidone-Iodine (Betadine)FDA LinkGeneric 11/01/1997 - "Clinical experience proved the efficacy of Betadine suppository in the treatment of bacterial vaginosis and mycotic infections of the vagina. " 01/01/2002 - "A prospective, randomized clinical trial was performed to study the efficacy of povidone iodine (Betadine) suppositories for the treatment of bacterial vaginosis (BV) in comparison to capsules containing lactobacilli (Döderlein Med). " 01/01/2002 - "Efficacy of povidone-iodine vaginal suppositories in the treatment of bacterial vaginosis." 01/01/1999 - "We carried out a prospective study aiming to estimate the frequency of vaginitis in women wanting to make an artificial abortion and the possibility to influence this infections by local application of vaginal BETADINE suppositories in all forms of infectious vaginitis: Candida albicans, trichomonas vaginalis and bacterial vaginosis." Order ALL the reference details at left...
9.	Lactic Acid FDA LinkGeneric 04/01/2008 - "Atopobium vaginae, a fastidious, anaerobic, Gram-positive cocci-shaped bacterium that generates large quantities of lactic acid, is associated with bacterial vaginosis (BV). " 08/01/2007 - "Certain lactobacilli produce H2O2 and lactic acid, which normally suppress growth of anaerobes; however, in bacterial vaginosis, Gardnerella vaginalis and other anaerobes proliferate, and the number of lactobacilli decreases. " 12/01/1994 - "Several attempts have recently been made to treat bacterial vaginosis using physiological or 'natural' substances, such as lactate gel and commercial yoghurt, which is acidic and also contains lactobacillus strains. " 01/01/1990 - "Bacterial vaginosis and the effect of intermittent prophylactic treatment with an acid lactate gel." 01/01/1990 - "10 pregnant women with bacterial vaginosis were treated vaginally with a low-pH lactate gel intermittently during 6 weeks. " Order ALL the reference details at left...
10.	SolcoTrichovacIBA 07/01/1994 - "An audit of Gynatren (a Lactobacillus acidophilus lyophilisate) vaccination in women with recurrent bacterial vaginosis." 01/01/1988 - "In a prospective, randomized double-blind study the prophylactic effect of the immunotherapeutic agent, Gynatren, against reinfection was investigated in 192 patients with bacterial vaginitis (95 treated with the active preparation versus 97 with placebo). " 05/01/1984 - "In view of the high cure rates of Trichomonas vaginitis after vaccination with the immunotherapeutic drug Solco Trichovac Gynatren, the therapeutic efficacy of this regimen in nonspecific vaginitis was investigated. " 01/01/1988 - "Bacterial vaginitis: protection against infection and secretory immunoglobulin levels in the vagina after immunization therapy with Gynatren." Order ALL the reference details at left...

Therapies and Procedures

1.	Aftercare (After-Treatment) 10/01/2004 - "OBJECTIVE: This study was undertaken to evaluate antimicrobial susceptibility of vaginal anaerobic bacteria before and after treatment of bacterial vaginosis. " 01/01/1997 - "Objective: The cure rate after treatment of bacterial vaginosis (BV) differs in various investigations, but most studies report a cure rate of 70% after 1 month.Methods" 02/01/2009 - "RECENT FINDINGS: New molecular techniques have increased our understanding of the numerous bacteria associated with bacterial vaginosis, and a biofilm containing mostly Gardnerella and Atopobium vaginae, which can persist after treatment has been described. " 07/01/2008 - "BACKGROUND: Bacterial vaginosis frequently persists after treatment. " 07/01/2008 - "Factors related to bacterial vaginosis that persists or occurs again after treatment in women who have sex with women." Order ALL the reference details at left...
2.	Condoms (Condom) 11/01/2007 - "When we excluded women with intermediate flora, consistent condom use was even more strongly protective against bacterial vaginosis (0.37 [0.20-0.70]). " 11/01/2007 - "BACKGROUND: Previous studies have been inconsistent with regard to whether condom use is associated with bacterial vaginosis. " 04/01/2009 - "Effect of consistent condom use on 6-month prevalence of bacterial vaginosis varies by baseline BV status." 11/01/2007 - "CONCLUSIONS: Consistent condom use was associated with a decrease in the risk for bacterial vaginosis and associated vaginal microflora." 11/01/2007 - "RESULTS: Consistent condom use (10 out of 10 sexual encounters) was associated with a decreased frequency of bacterial vaginosis (adjusted odds ratio = 0.55 [95% confidence interval 0.35-0.88]). " Order ALL the reference details at left...
3.	Intravaginal Administration 07/01/2008 - "Safe and effective long-term vaginal administration of Lactobacillus rhamnosus appears to be a useful complementary approach in the management of bacterial vaginosis." 01/01/2009 - "BACKGROUND: The dominance of lactobacilli in healthy vaginal microbiota and its depletion in bacterial vaginosis (BV) has given rise to the concept of oral or vaginal instillation of probiotic Lactobacillus strains for the management of this condition. " 01/01/2009 - "The data indicate that intravaginal administration of exogenous selected strains of lactobacilli can restore a normal vaginal microbiota and be used in treating bacterial vaginosis." 03/01/1999 - "GOAL OF THIS STUDY: The goal of this study was to compare the safety and efficacy of once-daily intravaginal administration of 0.75% metronidazole gel for 5 days to the established twice-daily regimen in the treatment of bacterial vaginosis. " 07/01/2008 - "Effectiveness of vaginal administration of Lactobacillus rhamnosus following conventional metronidazole therapy: how to lower the rate of bacterial vaginosis recurrences." Order ALL the reference details at left...
4.	Contraception (Birth Control) 07/01/2009 - "Hormonal contraception and risk of bacterial vaginosis diagnosis in an observational study of women attending STD clinics in Baltimore, MD." 07/01/2009 - "BACKGROUND: The protective effect of hormonal contraception may offer a potential intervention against bacterial vaginosis (BV). " 05/15/2005 - "Genital tract shedding of herpes simplex virus type 2 in women: effects of hormonal contraception, bacterial vaginosis, and vaginal group B Streptococcus colonization." 09/01/2000 - "Bacterial vaginosis and contraceptive methods." 06/01/1997 - "To determine whether bacterial vaginosis (BV) is associated with use of specific contraceptive methods, 956 women from family planning and youth clinics at 3 Swedish hospitals were enrolled in a cohort study. " Order ALL the reference details at left...
5.	Pessaries 01/01/2000 - "Bacterial vaginosis (BV) was noted in 32% of pessary users, versus 10% of controls. " 01/01/2000 - "Bacterial vaginosis increases in pessary users." 12/01/1990 - "Metronidazole pessaries are effective in the treatment of bacterial vaginosis." 12/01/1990 - "In a randomized, double-blind clinical trial from general practice, 500 mg metronidazole pessaries applied once daily for seven days were compared with placebo in the treatment of bacterial vaginosis. " 12/01/1990 - "Metronidazole pessaries compared with placebo in the treatment of bacterial vaginosis." Order ALL the reference details at left...

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