Abstract | CONTEXT: PURPOSE: The aim of the current study was to investigate the prevalence of hyperinsulinemia in nonobese Japanese subjects and to examine the involvement of insulin receptor gene mutations. METHODS: We enrolled 11,046 subjects who received health checkups. From these, we extracted nonobese subjects (body mass index <25 kg/m2) who exhibited hyperinsulinemia (serum fasting immunoreactive insulin ≥15 µU/mL). Genetic analysis was performed for the insulin receptor gene in 11 nonobese subjects with hyperinsulinemia. RESULTS: The prevalence of hyperinsulinemia without apparent diabetes in nonobese subjects was 0.4% (33/8630). In the 11 analyzed subjects, two novel heterozygous nonsense mutations were detected [c.2106 T>G (p.Y702X) and c.2779-2780 GC>A]. The prevalence of insulin receptor gene mutations was 18.2% (2/11). CONCLUSIONS:
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Authors | Shingo Fujita, Yohei Kuroda, Kenji Fukui, Ryuya Iwamoto, Junji Kozawa, Takehiko Watanabe, Yuya Yamada, Akihisa Imagawa, Hiromi Iwahashi, Iichiro Shimomura |
Journal | Journal of the Endocrine Society
(J Endocr Soc)
Vol. 1
Issue 11
Pg. 1351-1361
(Nov 01 2017)
ISSN: 2472-1972 [Print] United States |
PMID | 29264459
(Publication Type: Journal Article)
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