Nonsense Codon (Nonsense Mutation)

1154  relevant articles (11 outcomes, 45 trials/studies) found for this Bio-Agent

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Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Shimizu, Hiroshi: 4 articles (07/2008 - 12/2003)
2.	Akiyama, Masashi: 3 articles (07/2008 - 12/2006)
3.	Sakai, Kaori: 3 articles (07/2008 - 12/2006)
4.	Ma, Xu: 3 articles (01/2008 - 01/2007)
5.	Uitto, J: 3 articles (02/2001 - 01/2000)
6.	Zeviani, Massimo: 2 articles (09/2008 - 03/2007)
7.	Tiranti, Valeria: 2 articles (09/2008 - 03/2007)
8.	Fernandez-Vizarra, Erika: 2 articles (09/2008 - 03/2007)
9.	Gu, Feng: 2 articles (01/2008 - 01/2007)
10.	Shotelersuk, Vorasuk: 2 articles (12/2007 - 07/2007)

Related Diseases

1.	Infection 01/01/2009 - "The G428A nonsense mutation in FUT2 provides strong but not absolute protection against symptomatic GII.4 Norovirus infection." 08/01/2007 - "A strong correlation (P = 0.003) was found between the secretor phenotype and symptomatic disease, extending previous knowledge and confirming that nonsense mutations in the FUT2 gene provide protection against symptomatic norovirus (GGII.4) infections." 01/01/2009 - "To the best of our knowledge, this is the first example of symptomatic GII.4 norovirus infection of a Le(a+b-) individual homozygous for the G428A nonsense mutation in FUT2. " 03/21/2006 - "A nonsense mutation (428G-->A) in the fucosyltransferase FUT2 gene affects the progression of HIV-1 infection." 12/01/2005 - "A homozygous nonsense mutation (428G-->A) in the human secretor (FUT2) gene provides resistance to symptomatic norovirus (GGII) infections." Order ALL the reference details at left...
2.	Heart Failure 08/01/2004 - "RESULTS: Two new mutations leading to premature stop codons were identified in patients who evolved towards severe heart failure (< 25 years old): 657C>T and 173_179del. " 05/27/2004 - "We tested the hypothesis that possession of the C34T nonsense mutation in AMPD1 gene, which is known to improve survival in chronic heart failure, protects against cardiac dysfunction in donors. " 01/01/2005 - "Possession of the nonsense mutation in AMPD 1 C34T gene has been linked to improved survival in patients with heart failure, possibly by promoting the formation of adenosine. " 09/01/2003 - "OBJECTIVES: Possession of the C34T (Glu12Stop) nonsense mutation in the AMP-deaminase 1 (AMPD1) gene has been shown to be associated with improved prognosis in heart failure and ischemic heart disease. " Order ALL the reference details at left...
3.	Syndrome 12/01/2006 - "The current study investigated a cohort of 129 individuals, from 13 different families, who harbour the identical nonsense mutation (C1528T) in the hMLH1 gene, predisposing them primarily to Lynch I syndrome. " 03/01/2001 - "In the present study, we analyzed the AR gene in 8 patients, 4 sporadic and 2 familial cases with the syndrome, using exon-specific polymerase chain reaction, single-stranded conformational polymorphism and sequencing analysis and identified six new single base mutations, including one nonsense mutation at the hinge region of the receptor. " 02/28/2000 - "As well as providing further evidence that type 1 Stickler syndrome results from COL2A1 premature stop codon mutations, this study suggests mutant mRNA instability leading to haploinsufficiency may also be an important, but previously unrecognized, molecular basis of Stickler syndrome. " 11/01/2009 - "This finding suggests that both nonsense mutations and missense SCN2A mutations cause Dravet syndrome." 11/01/2009 - "In Dravet syndrome, only one nonsense mutation of SCN2A was identified, while hundreds of mutations were found in the paralogue gene, SCN1A, which encodes the alpha1 subunit. " Order ALL the reference details at left...
4.	Muscular Dystrophies (Muscular Dystrophy) 08/01/1999 - "Furthermore, these results raise the possibility of a novel treatment regimen for muscular dystrophy and other diseases caused by premature stop codon mutations. " 01/01/2009 - "By-passing the nonsense mutation in the 4 CV mouse model of muscular dystrophy by induced exon skipping." 04/01/2001 - "Mild muscular dystrophy due to a nonsense mutation in the LAMA2 gene resulting in exon skipping." 11/01/2004 - "[Possible chemotherapy of muscular dystrophy caused by nonsense mutation]" 01/01/2004 - "Cloned and sequenced in 1991, it was later shown to have nonsense mutations in recessive epidermolysis bullosa with muscular dystrophy. " Order ALL the reference details at left...
5.	Neoplasms (Cancer) 01/01/2006 - "BACKGROUND: The detection of Premature Stop Codons (PSCs) in human genes is very useful for the genetic diagnosis of different hereditary cancers, e.g. " 08/01/2009 - "These included an LOH analysis for copy number, real-time and methylation-specific polymerase chain reaction (PCR) to probe for BRCA2 promoter methylation, in addition to protein truncation testing (PTT) gel screening for nonsense BRCA2 mutations, and finally direct gene sequencing to either confirm the nonsense mutations or to detect candidate missense mutations in the remaining tumor samples. " 11/01/2008 - "The other APC allele in this tumor showed an acquired nonsense mutation, c.4132C --> T. " 08/01/2008 - "Tumor suppressor (TS) genes exhibit a disproportionate number of nonsense mutations while most mutations in oncogenes are missense. " 02/01/2007 - "Since nonsense mutations are closely associated with severe conditions of genetic disorders, including familial cancers, rapid and precise detection of those mutations is very important for research purposes and molecular diagnosis. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	RNA (Ribonucleic Acid)
2.	Messenger RNA (mRNA)
3.	DNA (Deoxyribonucleic Acid)
4.	Bilirubin
5.	Protein Sorting Signals (Signal Peptide)
6.	AMP Deaminase (Myoadenylate Deaminase)
7.	Adenosine
8.	Dystrophin
9.	Gentamicins (Gentamicin)
10.	Codon (Codons)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Cord Blood Stem Cell Transplantation
3.	Heterologous Transplantation (Xenotransplantation)
4.	Transplantation (Transplant Recipients)
5.	Combination Drug Therapy (Combination Chemotherapy)