Abstract | Background: Methods: Results: We identified 60 patients with IgAV-related nephritis (IgAV-N) and 25 patients without nephritis (IgAV-woN). At the time of inclusion (Day 1), the serum levels of galactose-deficient IgA1 (Gd-IgA1) and urinary concentrations of IgA, IgG, IgM, NGAL, interleukin (IL)-1β, IL-6, IL-8, IL-10, IgA- IgG and IgA-sCD89 complexes were higher in the IgAV-N patients than in the IgAV-woN patients (P < 0.005 for all comparisons). After follow-up (1 year), 22 patients showed a poor outcome. Among the tested markers, urine IgA at disease onset adequately reclassified the risk of poor outcome over conventional clinical factors, including estimated glomerular filtration rate, proteinuria and age (continuous net reclassification improvement = 0.72, P = 0.001; integrated discrimination improvement = 0.13, P = 0.009) in IgAV patients. Conclusions: Taken together, these results showed that serum Gd-IgA1 and urinary IgA, IgG, IgM, NGAL, IL-1β, IL-6, IL-8, IL-10, IgA- IgG and IgA-sCD89 complexes were associated with nephritis in IgAV patients. Urinary IgA level may improve patient risk stratification for poor outcome.
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Authors | Laureline Berthelot, Agnès Jamin, Denis Viglietti, Jonathan M Chemouny, Hamza Ayari, Melissa Pierre, Pierre Housset, Virginia Sauvaget, Margarita Hurtado-Nedelec, François Vrtovsnik, Eric Daugas, HSPrognosis Group, Renato C Monteiro, Evangeline Pillebout, members of the HSPrognosis Group |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 33
Issue 9
Pg. 1579-1590
(09 01 2018)
ISSN: 1460-2385 [Electronic] England |
PMID | 29126311
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antigen-Antibody Complex
- Biomarkers
- Immunoglobulin A
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Topics |
- Adult
- Aged
- Antigen-Antibody Complex
(analysis)
- Biomarkers
(analysis)
- Female
- Glomerular Filtration Rate
- Humans
- IgA Vasculitis
(blood, complications)
- Immunoglobulin A
(blood)
- Male
- Middle Aged
- Nephritis
(blood, etiology)
- Prognosis
- Prospective Studies
- ROC Curve
- Young Adult
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