Abstract | Background: Results: Plantar incision induced mechanical hypersensitivity in the ipsilateral hind paw that peaked one day and lasted for three days after the surgery. Treatment with colchicine significantly attenuated the early infiltration of Gr1-positive cells (neutrophils) around the incision site and mechanical hypersensitivity, which was accompanied with inhibition of the subsequent infiltration of Iba1-positive cells (macrophages) and macrophage polarization toward the proinflammatory M1 phenotype. By contrast, an intravenous injection of clodronate liposomes significantly inhibited the infiltration of macrophages around the incision site but had little effect on the infiltration of neutrophils or mechanical hypersensitivity. Importantly, colchicine treatment significantly delayed wound closure after the incisional surgery, whereas clodronate liposome administration had no effect on wound closure. Conclusion: These results suggest that colchicine can alleviate acute postoperative pain and also enhance the risk of delayed wound repair, which are associated with the suppression of neutrophil and subsequent proinflammatory M1 macrophage infiltration around the incision site, while the involvement of macrophages may be limited.
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Authors | Asami Sukeishi, Koichi Isami, Haruka Hiyama, Satoshi Imai, Kazuki Nagayasu, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko |
Journal | Molecular pain
(Mol Pain)
2017 Jan-Dec
Vol. 13
Pg. 1744806917743680
ISSN: 1744-8069 [Electronic] United States |
PMID | 29108466
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Acute Pain
(drug therapy)
- Animals
- Colchicine
(pharmacology)
- Disease Models, Animal
- Hyperalgesia
(drug therapy)
- Inflammation
(drug therapy)
- Macrophages
(drug effects)
- Male
- Mice, Inbred C57BL
- Neutrophils
(drug effects)
- Pain, Postoperative
(drug therapy)
- Wound Healing
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