Association between growth differentiation factor 15 and left ventricular hypertrophy in hypertensive patients and healthy adults.

Abstract

Growth differentiation factor 15 (GDF-15) as an independent biomarker of cardiovascular diseases merits further evaluation. We studied the association between plasma GDF-15 levels and left ventricular hypertrophy (LVH) in hypertensive patients and healthy adults. Hypertensive LVH measurements were performed via echocardiography and analyzed using the cube formula, and human GDF-15 together with interleukin-6 (IL-6) and matrix metalloproteinase-9 (MMP-9) concentrations were determined via enzyme-linked immunosorbent assay (ELISA). All data were analyzed using SPSS 13.0 software. A total of 302 participants were recruited for this clinical study. Circulating GDF-15, IL-6 and MMP-9 levels were significantly higher in LVH patients (n = 67) than in non-LVH patients (n = 172) and healthy controls (n = 63) (p < 0.001). After adjustment for confounders via multivariate logistic regression, elevated plasma GDF-15 concentrations remained independently associated with LVH in hypertensive patients. In addition, GDF-15 was positively correlated with IL-6 and MMP-9 levels in human plasma, respectively, suggesting that a link exists between GDF-15 expression and inflammation. We also calculated an optimal GDF-15 cut-off point with which LVH severity can be predicted in the current study. In conclusion, GDF-15 is associated with hypertensive LVH and may be a powerful biomarker with which LVH risk can be predicted in patients with hypertension.

• Authors: Huijuan Kou, Xin Jin, Dengfeng Gao, Rui Ma, Xin Dong, Jin Wei, Xin Wang
• Journal: Clinical and experimental hypertension (New York, N.Y. : 1993) (Clin Exp Hypertens) Vol. 40 Issue 1 Pg. 8-15 ( 2018) ISSN: 1525-6006 [Electronic] England
• PMID: 29035099 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Biomarkers
• GDF15 protein, human
• Growth Differentiation Factor 15
• Interleukin-6
• Matrix Metalloproteinase 9

Topics

• Adult
• Aged
• Biomarkers (blood)
• Cardiovascular Diseases (complications)
• Case-Control Studies
• Echocardiography
• Female
• Growth Differentiation Factor 15 (blood)
• Humans
• Hypertension (blood, complications)
• Hypertrophy, Left Ventricular (blood, diagnostic imaging, etiology)
• Interleukin-6 (blood)
• Logistic Models
• Male
• Matrix Metalloproteinase 9 (blood)
• Middle Aged