Periostin in inflammation and allergy.

Abstract

We found for the first time that IL-4 and IL-13, signature type 2 cytokines, are able to induce periostin expression. We and others have subsequently shown that periostin is highly expressed in chronic inflammatory diseases-asthma, atopic dermatitis, eosinophilc chronic sinusitis/chronic rhinosinusitis with nasal polyp, and allergic conjunctivitis-and that periostin plays important roles in the pathogenesis of these diseases. The epithelial/mesenchymal interaction via periostin is important for the onset of allergic inflammation, in which periostin derived from fibroblasts acts on epithelial cells or fibroblasts, activating their NF-κB. Moreover, the immune cell/non-immune cell interaction via periostin may be also involved. Now the significance of periostin has been expanded into other inflammatory or fibrotic diseases such as scleroderma and pulmonary fibrosis. The cross-talk of periostin with TGF-β or pro-inflammatory cytokines is important for the underlying mechanism of these diseases. Because of its pathogenic importance and broad expression, diagnostics or therapeutic drugs can be potentially developed to target periostin as a means of treating these diseases.

• Authors: Kenji Izuhara, Satoshi Nunomura, Yasuhiro Nanri, Masahiro Ogawa, Junya Ono, Yasutaka Mitamura, Tomohito Yoshihara
• Journal: Cellular and molecular life sciences : CMLS (Cell Mol Life Sci) Vol. 74 Issue 23 Pg. 4293-4303 (12 2017) ISSN: 1420-9071 [Electronic] Switzerland
• PMID: 28887633 (Publication Type: Journal Article, Review)

Chemical References

• Anti-Inflammatory Agents
• Cell Adhesion Molecules
• IL4 protein, human
• Interleukin-13
• NF-kappa B
• POSTN protein, human
• Transforming Growth Factor beta
• Interleukin-4

Topics

• Anti-Inflammatory Agents (therapeutic use)
• Cell Adhesion Molecules (antagonists & inhibitors, genetics, immunology)
• Dermatitis, Atopic (drug therapy, genetics, immunology, pathology)
• Epithelial Cells (drug effects, immunology, pathology)
• Fibroblasts (drug effects, immunology, pathology)
• Gene Expression Regulation
• Humans
• Hypersensitivity (drug therapy, genetics, immunology, pathology)
• Inflammation
• Interleukin-13 (genetics, immunology)
• Interleukin-4 (genetics, immunology)
• Mesenchymal Stem Cells (drug effects, immunology, pathology)
• NF-kappa B (antagonists & inhibitors, genetics, immunology)
• Signal Transduction
• Transforming Growth Factor beta (genetics, immunology)