PARP-1 serves as a novel molecular marker for hepatocellular carcinoma in a Southern Chinese Zhuang population.

Abstract

PARP-1 (poly(ADP-ribose) polymerase-1) plays an important role in tumorigenesis. Since its effects on different populations are varied, this study investigated the impact of PARP-1 on primary hepatocellular carcinoma in a Southern Chinese Zhuang population. We assessed the global PARP-1 messenger RNA expression in patients with hepatocellular carcinoma using The Cancer Genome Atlas dataset. Increased PARP-1 expression, related to alpha-fetoprotein level, was observed. The area under the receiver operating characteristic curve value was 0.833. Kaplan-Meier survival curves indicated that higher PARP-1 expression was not correlated with poorer overall survival and recurrence-free survival. In a Zhuang population, PARP-1 messenger RNA and protein levels were increased in the hepatocellular carcinoma tissue and its adjacent liver tissues as assessed by quantitative polymerase chain reaction, immunohistochemistry, and western blotting. Higher PARP-1 level was associated with a higher tumor stage (p < 0.05), without correlation with age, gender, smoking, drinking, tumor size, serum alpha-fetoprotein level, hepatitis B virus infection, metastasis, and invasion (p > 0.05). Further analysis suggested that H2AX, a PARP-1 protein interaction partner, was coordinated with PARP-1 in hepatocellular carcinoma tumorigenesis. Overall, some new characteristics of PARP-1 expression were noted in the Zhuang population. PARP-1 is a novel promising diagnostic marker for hepatocellular carcinoma in the Southern Chinese Zhuang population.

• Authors: Jiatong Li, Dongwei Dou, Ping Li, Wenqi Luo, Wenxin Lv, Chengdong Zhang, Xiaowei Song, Yuan Yang, Yuening Zhang, Yanzhen Xu, Feifan Xiao, Yan Wei, Jian Qin, Hongtao Li, Xiaoli Yang
• Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol) Vol. 39 Issue 7 Pg. 1010428317706914 (Jul 2017) ISSN: 1423-0380 [Electronic] Netherlands
• PMID: 28714367 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• H2AX protein, human
• Histones
• alpha-Fetoproteins
• PARP1 protein, human
• Poly (ADP-Ribose) Polymerase-1

Topics

• Adult
• Aged
• Biomarkers, Tumor (genetics)
• Carcinogenesis (genetics)
• Carcinoma, Hepatocellular (genetics, pathology)
• Disease-Free Survival
• Female
• Gene Expression Regulation, Neoplastic
• Histones (genetics)
• Humans
• Kaplan-Meier Estimate
• Liver Neoplasms (genetics, pathology)
• Male
• Middle Aged
• Poly (ADP-Ribose) Polymerase-1 (genetics)
• alpha-Fetoproteins (genetics)