Abstract | BACKGROUND: In biliary atresia mechanisms of progressive liver injury leading to need of liver transplantation after successful portoenterostomy remain unknown. A better understanding is a prerequisite for development of novel therapies to extend native liver survival, and we aimed to unravel molecular characteristics of liver injury after successful portoenterostomy. METHODS: RESULTS: CONCLUSION: These findings suggest that instead of inflammation, molecular signature of active fibrogenesis in association with ductal reactions prevails in long-term native liver survivors with biliary atresia. Patients should be stratified for isolated and syndromic disease forms in interventional studies.
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Authors | Anna Kerola, Hanna Lampela, Jouko Lohi, Päivi Heikkilä, Annika Mutanen, Hannu Jalanko, Mikko P Pakarinen |
Journal | Surgery
(Surgery)
Vol. 162
Issue 3
Pg. 548-556
(09 2017)
ISSN: 1532-7361 [Electronic] United States |
PMID | 28655415
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2017 Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- Quinazolines
- SMA-41
- RNA
- Keratins
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Topics |
- Biliary Atresia
(genetics, pathology, surgery)
- Biomarkers
(metabolism)
- Biopsy, Needle
- Case-Control Studies
- Child, Preschool
- Female
- Follow-Up Studies
- Humans
- Immunohistochemistry
- Infant
- Keratins
(genetics)
- Liver Cirrhosis
(pathology, surgery)
- Liver Function Tests
- Liver Transplantation
(methods, mortality)
- Male
- Portoenterostomy, Hepatic
(adverse effects, methods, mortality)
- Quinazolines
(metabolism)
- RNA
(genetics)
- Reoperation
- Retrospective Studies
- Risk Assessment
- Severity of Illness Index
- Statistics, Nonparametric
- Survival Rate
- Time Factors
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