Bile Acids and Salts (Bile Acids)

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2880 relevant articles (103 outcomes, 281 trials/studies) found for this Bio-Agent

Description: Steroid acids and salts. The primary bile acids are derived from cholesterol in the liver and usually conjugated with glycine or taurine. The secondary bile acids are further modified by bacteria in the intestine. They play an important role in the digestion and absorption of fat. They have also been used pharmacologically, especially in the treatment of gallstones.

Also Known As:

Bile Acids; Acids, Bile; Salts, Bile; Bile Salts

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 59

Steroids: 14366

Bile Acids and Salts: 2880

Cholic Acids: 7

bile acid sulfates: 5

Experts

1.	Holubec, Hana: 3 articles (09/2007 - 02/2006)
2.	Dvorak, Katerina: 3 articles (09/2007 - 02/2006)
3.	Trauner, Michael: 3 articles (03/2007 - 07/2004)
4.	Chen, W: 3 articles (01/2007 - 01/2003)
5.	Gluud, C: 3 articles (01/2007 - 01/2003)
6.	Marschall, Hanns-Ulrich: 3 articles (05/2006 - 12/2002)
7.	Araki, Yoshio: 2 articles (05/2008 - 11/2002)
8.	Bresalier, Robert S: 2 articles (11/2007 - 04/2005)
9.	Song, Shumei: 2 articles (11/2007 - 04/2005)
10.	Sampliner, Richard E: 2 articles (09/2007 - 06/2007)

Related Diseases

1.	Pruritus (Itching) 08/01/1996 - "CONCLUSIONS: These findings show that UDCA is more effective than SAMe in controlling pruritus and total bile acids, which are considered a prognostic parameter in ICP with respect to the fetus. " 10/01/1981 - "Serum bile acids levels fell in all patients in whom pruritus improved but not in the patient who responded less favorably." 01/01/2008 - "CONCLUSION: This study suggests that women who have transient pruritus with normal bile salts and liver biochemistry appear to have higher intrapartum and postpartum complications and require increased vigilance. " 01/01/2008 - "Pruritus secondary to increased bile salts in the serum may not respond to medical treatment. " 01/01/2008 - "METHODS: The maternal and fetal outcomes of 144 women with pruritus but normal bile salts and LFTs were compared with the next delivered patient without itch who matched for age, ethnicity and parity. " Order ALL the reference details at left...
2.	Cholestasis 01/01/2003 - "CONCLUSION: The results demonstrate that there is a functional adaptive downregulation of renal tubular bile acid transport enhancing renal clearance of bile acids during the early phase of an obstructive cholestasis." 03/24/1989 - "These findings indicate that altered metabolism, such as 1 beta- or 6 alpha-hydroxylation of bile acids, is enhanced in cholestasis, and that the resulting hydroxylated metabolites are eliminated in the urine." 07/01/2008 - "In conclusion, the present study clearly demonstrated that OAT3 is responsible for renal secretion of bile acids during cholestasis and that the pharmacokinetic profile of OAT3 substrates may be affected by cholestasis." 09/01/2006 - "Chronic injection of EE (2 mg/kg, s.c., for 14 days) induced cholestasis as documented by increased serum concentrations of bile acids and caused a higher incidence of body scratching compared to vehicle, thus providing an animal model to study scratching behavior secondary to cholestasis. " 07/01/2006 - "Recent studies have begun to characterize the cellular and molecular mechanisms of hepatocyte injury caused by the retention of hydrophobic bile acids in cholestasis. " Order ALL the reference details at left...
3.	Gallstones (Gallstone) 02/01/1998 - "Bile salts and pigment content were significantly greater in gallstone-free controls than in all other disease study groups. " 11/01/1982 - "To test the comparative efficacy of these two cholelitholytic bile acids, 223 gallstones patients were randomly treated with either UDCA or CDCA at two different doses: 7 to 8 mg per kg per day and 14 to 15 mg per kg per day. " 02/01/1999 - "In this study we wanted to evaluate the long term recurrence of gallstones after stone clearance with ESWL and oral bile acids, and to assess possible risk and preventive factors of stone recurrence. " 01/01/1999 - "The aim of this study was to evaluate the profiles of fecal bile acid in gallstone patients, in order to estimate the quality and amount of fecal bile acids. " 04/01/1997 - "RESULTS: Bile salts and pigment content were greater in gallstone-free controls than in all other study groups, including morbidly obese gallstone-free subjects. " Order ALL the reference details at left...
4.	Liver Diseases (Liver Disease) 02/01/2009 - "As a novel, non-invasive marker of liver damage, we studied the efficacy of urine bile acids (UBA) in a rat model of liver disease. " 02/01/1995 - "Ursodeoxycholate (UDCA), a hydrophilic bile salt, ameliorates hepatocellular injury by toxic bile salts and is used to treat cholestatic liver disease. " 12/01/1979 - "Clearance of bile acids seems to be unimpaired in all except severe liver disease. " 03/01/1978 - "Determination of serum bile acids is helpful for screening and follow up of liver diseases, it gives however only little support in the differentiation of various hepatic diseases. " 11/01/2004 - "Although this preliminary study could not establish a causal relationship between cholemia and oxidative stress, we believe this model is worthy of further investigation to study the impact of short-term and long-term cholemia on diverse physiological and biochemical functions such as trying to establish a causal role for bile acids in the development of oxidative stress in cholestatic liver disease." Order ALL the reference details at left...
5.	Intrahepatic Cholestasis 10/01/1992 - "These results may indicate that UDCA is effective for the intrahepatic cholestasis in the case with no bile duct epithelial damage but in the presence of it hepato-cellular injury is introduced by the accumulated toxic bile acids in the blood." 12/01/2007 - "CONCLUSION: This study demonstrated that HGF is a novel regulator of CYP7A1 and bile acid synthesis in human hepatocytes and may protect hepatocytes from accumulating toxic bile acids and developing intrahepatic cholestasis during the early stage of liver regeneration." 03/01/2002 - "Mutations in the corresponding ABCB11 gene cause progressive familial intrahepatic cholestasis type 2. The aim of this study was to investigate the regulation of human ABCB11 gene transcription by bile salts. " 01/01/1991 - "To study a possible effect of the concentration of bile acids on the umbilical circulation we performed pulse-wave Doppler velocimetry of the umbilical artery in 15 patients with intrahepatic cholestasis between 34 and 38 weeks of gestation. " 01/01/2008 - "RESULTS: Bile acids were measurable in the bronchoalveolar lavage fluid of all of the infants in the intrahepatic cholestasis of pregnancy group but were absent in the 2 control groups. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Cholesterol
2.	Ursodeoxycholic Acid (Urso)
3.	Bilirubin
4.	Alkaline Phosphatase
5.	Alanine Transaminase (SGPT)
6.	Acids
7.	Enzymes
8.	Aspartate Aminotransferases (Aspartate Transaminase)
9.	Ammonia
10.	Creatinine

Related Therapies and Procedures

1.	Lithotripsy (Extracorporeal Shockwave Lithotripsy)
2.	Oral Administration
3.	Cholecystectomy
4.	Transplantation (Transplant Recipients)
5.	Jejunoileal Bypass

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