The relationship of serum adipokines with malnutrition inflammation score in haemodialysis.

Abstract

BACKGROUND:

Protein-energy wasting is a prevalent disorder in haemodialysis. Zinc-α2-glycoprotein (ZAG) and adipose triglyceride lipase (ATGL) are novel adipokines with recognized lipolytic effects and proposed role in metabolic homoeostasis. This study was conducted to investigate the association of ZAG and ATGL concentrations with malnutrition-inflammation score (MIS) and metabolic profile of patients with haemodialysis.

MATERIALS AND METHODS:

Eighty-eight patients under regular haemodialysis were divided based on MIS to normal to mild wasting (NMW; n = 35) or moderate wasting (MW; n = 53) group. Anthropometric measurements along with fasting serum concentrations of ZAG, ATGL, free fatty acids (FFAs), albumin, transferrin, total iron-binding capacity (TIBC), hs-CRP, lipid profile and glucose metabolism were assessed.

RESULTS:

Adipose triglyceride lipase concentration was significantly higher in MW than NMW group (10·89 ± 5·7 vs. 8·02 ± 3·37 mIU/mL; P = 0·008). The ZAG and FFAs were not significantly different between two groups. ATGL was directly correlated with FFAs in all of the patients (r = 0·284, P = 0·007) and MW (r = 0·32, P = 0·021), and marginally in NMW (r = 0·31, P = 0·057) groups. ATGL and odds of having mild or moderate wasting were significantly correlated (OR = 1·21, P = 0·033). A positive association was observed between ATGL with TG (r = 0·31, P = 0·049) and also with transferrin and TIBC (r = 0·44, P = 0·001) only in MW group. An inverse relationship was observed between ATGL and HDL in all of the participants (r=-0·222, P = 0·04). No significant correlation was observed between ZAG and other parameters.

CONCLUSIONS:

The serum concentrations of ATGL, but not ZAG, were significantly higher in MW compared to NMW group. Each unit increase in ATGL concentrations was correlated with 21% increase in the odds of wasting severity. ATGL might play a role in wasting pathogenesis and metabolic profile in haemodialysis.

• Authors: Elham Alipoor, Ahmad Esmaillzadeh, Mitra Mahdavi-Mazdeh, Mehdi Yaseri, Narges Sadat Zahed, Mohammad Javad Hosseinzadeh-Attar
• Journal: European journal of clinical investigation (Eur J Clin Invest) Vol. 47 Issue 8 Pg. 545-554 (Aug 2017) ISSN: 1365-2362 [Electronic] England
• PMID: 28621798 (Publication Type: Journal Article, Multicenter Study)
• Copyright: © 2017 Stichting European Society for Clinical Investigation Journal Foundation.

Chemical References

• Adipokines
• Seminal Plasma Proteins
• Zn-Alpha-2-Glycoprotein
• Lipase
• PNPLA2 protein, human

Topics

• Adipokines (metabolism)
• Body Mass Index
• Cross-Sectional Studies
• Female
• Humans
• Kidney Failure, Chronic (blood, therapy)
• Lipase (metabolism)
• Male
• Middle Aged
• Panniculitis (blood)
• Protein-Energy Malnutrition (blood, etiology)
• Renal Dialysis
• Seminal Plasma Proteins (metabolism)
• Zn-Alpha-2-Glycoprotein